VitaPulse is an “advanced antioxidant formula” designed to “support a healthy heart and circularity system.” That pretty much sums up what this supplement is supposed to do. Pretty plain and simple. So, does VitaPulse work? In this review, let's look at the ingredients in VitaPulse and see what they say. Along the way, I'll also try to drill down further and try to find out which of the ingredients have the most and least amount of evidence too. Leave a comment below if you have any questions.
Who Is VitaPulse For?
The product website (PrincetonNutrients.com), plainly states that VitaPulse is designed to help support a “healthy heart.” No place on the product website do they say VitaPulse should be used by people who are not “healthy,” in other words, people who already have heart problems. I actually appreciated this. I think this is worth mentioning for those with heart issues who are looking for natural treatments for their heart disease. For those with heart disease who are considering VitaPulse, show the ingredients to your doctor and pharmacist. Let them guide you on whether the product is right for you.
What Does VitaPulse Do?
From the website of the company that makes it (PrincetonNutrients), VitaPulse is said to help “support a healthy heart and circulatory system by delivering NAC, PQQ, and CoQ10 in supplement form.”
It's said to do this because:
- As antioxidants: NAC, PQQ & CoQ10 can help protect against cellular damage and threat inflammation to the heart.
- PQQ “may promote the creation and regrowth of mitochondria within cells.”
- “NAC acts as a precursor to glutathione.”
I'll look at the research on these claims in the research section below.
Because the ingredients in VitaPulse looked intriguing, I was curious if there was any research published on this supplement. I searched ClincalTrials.gov for “VitaPulse” but no studies showed up.
I then searched the National Library of Medicine (Pubmed.gov) for “VitaPulse.” Again, I saw no relevant studies show up.
I then googled the phrase “VitaPulse research.” No studies on the product showed up.
Therefore, I'm forced to conclude at this time that the VitaPluse supplement – itself – appears to have no published, peer reviewed studies. That's true for many supplements. I'll update this section as I become aware of research on the product. But, lack of research doesn't necessarily mean something doesn't work.
So, in the next section I want to cover some of the research on each of the products ingredients. If we know the research on the ingredients, this can help us better understand how the product might work.
According to the product I found on Amazon, these are the ingredients in each VitaPulse capsule:
|Ingredient||Amount Per Serving||Percent Daily Value|
|NAC (N-acetyl cysteine)||250 mg||N/A|
|Co Q 10||100 mg||N/A|
|PPQ (Pyrroloquinoline quinone)||10 mg||N/A|
A bottle has 30 capsules. In the table above “N/A” means no daily value has been established.
“Other ingredients” also listed are silica and vegetable cellulose. My guess is these ingredients are used in the capsules and play no role in the effects of the product.
Let's look at some of the research on each of these ingredients as they pertain to heart health and cholesterol levels.
VitaPulse Ingredients Research
From the table above, we can see that vitapulse has 3 active ingredients. Here is a summary of the heart-health related research on each of the ingredients.
The letters NAC stand for N-Acetyl-Cysteine (say “N-ah-sea-till-sis-teen). This compound comes from an amino acid called, cysteine. NAC helps us make a powerful antioxidant called glutathione.
This raising of glutathone levels is likely one of the main reasons people take NAC supplements.
There are glutamine supplements out there. But, it's probably better to take NAC than glutatione supplements . That's because glutathione supplements are not absorbed well but NAC supplements are. As such, NAC supplements can raise glutathione levels in the body.
NAC appears to raise nitric oxide levels according to at least one study. Nitric oxide is a gas that can expand blood vessels. By increasing the diameter of blood vessels, this can help reduce chest pains due to angina. Some research also notes that NAC – when used along side nitroglycerin therapy – might reduce angina pain.
For those using nitroglycerin tables for heart disease, please don't start taking NAC without first speaking to your doctor and pharmacist first. The combination make your blood pressure go too low.
NAC might also reduce homocysteine levels. This is a compound that may be related to heart disease. The studies I saw noting it did this, used about 1000 mg which is more NAC than is in VitaPluse. It's worth noting that the connection between homocysteine and heart disease is controversial.
A less expensive way to reduce homocysteine is to eat more fruits and vegetables. The vitamin called folate (also called folic acid), along with B12 and B6 can also reduce homocysteine and have many other benefits also.
If you don't like eating these foods, see my smoothie recipe.
This bookprovides a fascinating and easy to understand review of preventing and reversing heart disease though diet.
Another name for this is Coenzyme Q10. Still another name is Ubiquinone which is pronounced “U-bik-wa-qwa-known.”
There are many studies attesting to the effects of CoQ 10 on heart health. It's so popular that it's been widely used in Japan since the 1970s to help heart disease. Its also been studied extensively to treat many other conditions as well ranging from immune system health to hearing loss.
CoQ10 supplements have been shown to improve critical markers of heart health such as ejection fraction, cardiac output and stroke volume.
CoQ10 has also been shown to reduce blood pressure.
As for cholesterol levels, I think more research is needed. In this 2011 study of 51 overweight people, 200 mg of CoQ10, given for 12 weeks, did not seem to lower cholesterol levels.
Generally, studies have used 60-300 mg per day to achieve benefits. VitaPlus has 100 mg per capsule so it is in this range. That's good. CoQ10 should be taken with food to increase its absorption. I also feel 100mg is a better dosage for most generally healthy people as, its better absorbed at this amount than, say 300 mg.
The letters PQQ stand for Pyrroloquinoline quinone. It's pronounced “pie-role-low-quin-a-lean-kwin-own.”Another name for PQQ that is sometimes used is methoxatin.
Most people however call just it “PQQ.”
This compound has antioxidant effects and is also sometimes called a redox agent. The word redox means PQQ takes part in antioxidant and free radial reactions such as those that occur inside the mitochondria. PQQ is not a vitamin. It's more of a psudo-vitamin.
See my review of ASEA Water for more on redox agents.
Animal research suggests that PQQ helps the mitochondria work better and might also help us make more mitochondria. The mitochondria, often called the “powerhouses of the cell” are actually little fat burning batteries inside our cells.
Because defects in how the mitochondria work is thought to play a role in aging, some might refer to PQQ as the “fountain of youth” for our mitochondria. Obviously aging is a very complicated phenomenon (if it wasn't we would have figured it out by now).
To counter the hype about this on some websites, I'd respectively point out that references to PQQ being the “fountain of youth” stem mostly from the effects of the compound on the mitochondria of lab animals and in test tubes. In other words, where are the people studies?
According to this study from 1995, foods that with the highest levels of PQQ include:
|Kiwi fruit||Sweet potatoes||Fermented soybeans|
In a 2013 human study, 10 young adults were given between 0.2 and 0.3 grams of PQQ per kilogram. For a 160 pound person, that's about 14 mg to 21 mg per day. This study noticed that PQQ reduced CRP levels, which are a marker for inflammation in the body.
Heart disease (and other disorders) does appear to be linked to, at least in part, to an increase in cellular inflammation.
This study did not note any decrease in triglyceride levels. Triglycerides also play a role in heart disease.
In a 2015 study, 29 healthy adults were given either a placebo or 20 mg of PQQ per day for 12 weeks. Some of these people had high levels of “bad” cholesterol (LDL cholesterol) and triglycerides.
Using PQQ for 12 weeks did not reduce triglyceride levels but had a mild yet significant effect on LDL levels in the people whose levels were high. In these people, the LDL decreased from 136 to 127. But, that is still considered “high” so the effect of PQQ on LDL looks modest at best.
VitaPulse contains 10mg of PQQ per capsule. This is in line with what some human studies are using, so that's good. I still feel we need more human research to know how much might be best for people. Some websites that discuss PQQ often say that people should aim for 10-20 mg per day. This range is likely based on the human and animal studies conducted so far.
Much of the buzz about PQQ surrounds its effects on the mitochondria. PQQ may very well one day live up to this hype. But, I would be remiss if I did not point out that exercise has also been shown to grow mitochondria too.
How Much To Take?
The product website recommends taking 1 Vitapulse per day. Since each bottle has 30 capsuels, a bottle will last a month.
What About UltraKrill?
When I checked the product website, I noticed they had another supplement called UltraKrill. This product is a krill oil supplement. Krill are tiny animals that fish eat. The oil is extracted from these animals.
Krill oil contains both EPA and DHA (“the fish oils”). Because of this, there has been interest in krill oil as an alternative to fish oil supplements.
While krill oil might have a blood thinning effect, as fish oil does, there are not as many human studies as there are for fish oil supplements (and eating fish). I have met people who told me it helped their cholesterol levels but I'm not yet convinced of it's benefits. I think we need better studies on krill oil. For people who are “healthy” I think krill oil supplements are safe.
Who Makes VitaPulse?
The company is called Princeton Nutrients, LLC. According to the products website (PrincetonNutrients.com), they are located at 6303 Owensmouth Avenue, 10th Floor
Woodland Hills, CA, 91367-2263. If you google the address you can see that there is a large office building located at this address called the Warner Center Business Center. My guess is this building houses several different businesses.
Despite the name of the company, as far as I can tell, there appears to be no connection to Princeton University.
The address for the company at the Better Business Bureau website is 20929 Ventua Blvd Ste 47-503, Woodland Hills, CA 91364. When I googled this address, I saw a UPS Store. I also saw an optometrist office. It's quite possible these are older addresses.
Update: The BBB has changed the address on their site to the Owensmouth Ave address to reflect what is on the product website.
According to the whois.com file for the website, it was created on 5/7/15. The Better Business Bureau notes they first started a file on Princeton Nutrients on 8/11/15.
The BBB gave Princeton Nutrients a rating of “F” when this review was created. Because the BBB often changes their ratings, see the BBB file for updates and more information.
Update. As of 7/13/16, the BBB has upgraded the company to a rating of “A-“
Update. As of 9/28/16, there was no rating.
Update: As of 5/31/17, the company had an “A” rating.
This normally happens over time as the BBB updates ratings. See the BBB file for updates and more information.
How To Contact VitaPulse
The VitaPulse.com website provides this customer support number:866-427-3019. Their website is PrincetonNutrients.com .
How Much Does VitaPulse Cost?
When I checked Amazon, I saw VitaPulse listed for $74.79. On the PrincetonNutrients.com site, they had a bottle listed for $49 + $6.95 shipping. The product website also had additional deals when purchasing multiple bottles.
There was no auto-ship program when this review was created. In other words, if you buy from the company website, they will not automatically send you new orders or bill you on a regular basis. This is refreshing and I liked this.Vitapulse may be on Amazon too.
Make Your Own VitaPulse
Those who want to try VitaPulse but can't afford it might be wondering if they could make their own by purchasing its individual ingredients. I think you can. Remember that VitaPulse only has 3 ingredients:
- COQ10 (100 mg) (click to see Amazon price)
- NAC (250 mg) (click to see Amazon price)
- PQQ (10 mg) Click to see Amazon price)
Depending on the brand of ingredients you purchased, if you bought the ingredients separately, you might pay less than $50. Because PQQ has the least human evince, I think you could leave this out and save more.
Of course, the downside to purchasing the ingredients separately would be that you'd be taking 2-3 pills a day as opposed to only 1 capsule with VitaPulse. I just wanted to mention this for those on a budget who were interested in this product.
VitaPulse Side Effects
I believe VitaPulse is likely safe in healthy people. As a rule, those who are not “healthy” should get their doctors permission first. I'd also show the ingredients to your pharmacists too if you take any medications. They know a lot about supplements and drug interactions.
A short list of people who should get permission from their doctor first include those who have heart disease, liver problems, people taking blood thinner medications and those who have high or low blood pressure.
Stop taking all supplements not recommended by your doctor at least 2 weeks before having surgery.
Pregnant and/or nursing mothers should speak to their doctors first.
Here is a few things that occurred to me as I looked at the research on the ingredients in this product. This list is not complete:
CoQ10 might reduce blood pressure. In theory, this might interact with blood pressure medications. CoQ10 might also interfere with blood thinner medications. There is some speculation that CoQ10 (and other antioxidants) might interfere with some cancer therapies.
Speak to your doctor first if using drugs for erectile dysfunction, heart disease or high (or low) blood pressure.
People with cancer should speak with their oncologist before taking NAC supplements. There is some preliminary evidence (animal and test tube studies) that NAC might be bad if you have cancer.
Does VitaPulse Work?
While it would take human studies on VitaPulse to know for sure, the ingredients in the product do make sense for the most part, so it's possible some people might benefit from it. While it's possible all the ingredients work in conjunction with each other to provide a broad spectrum of heart support, of all the ingredients in VitaPulse, I see the most human evidence for CoQ10. That makes me wonder if CoQ10 might be the main active ingredient in VitaPulse.