I thought Nerium was a skin care company because until recently, everything I saw about were glowing reviews of women who said it was great for their skin and complexion. I had no idea Nerium had supplements too – until I became aware of a memory product called Nerium EHT. In this review, I’m going to look the research -and the nature of the research – of the Nerium EHT itself and its ingredients as it pertains to improving memory. My goal is to help give you an idea if Nerium EHT might be right for you. Let’s see what we can discover. Also see my review of Cebria for more info on that memory supplement.
Who Makes Nerium EHT?
Nerium EHT is a product of Nerium International, LLC. The EHT in the supplement comes from another company called Signum Biosciences. I will briefly look at each company separately.
According to the company website (Nerium.com), Nerium International is a “relationship marketing company.” That means they offer a variety of products which are sold via distributors, called “Nerium Brand Partners.” Basically, Nerium is a multi-level marketing company. Nothing wrong with that. The Nerium website lists their address as:
4006 Belt Line Road Addison , TX 75001. The address listed with the Better Business Bureau is a bit different than this, but in the same office building: 4004 Belt Line Rd STE 112, Addison, TX 75001-4356.
Each address corresponds to the same business center. If you Google the address you can see what it looks like.
The BBB gave Nerium International a rating of “A +” at the time I wrote this review. Thats good. Nerium is also a BBB accredited business so that’s good too. See the BBB file for updates and additional information.
This is the company that discovered the EHT molecule. They are a privately held biotechnology company that is located at 133 Wall Street Princeton, NJ 08540. Their website (SignumBiosciences.com) lists this contact phone number: 732.329.6344. I’ll review the research on the EHT compound below.
Nerium EHT Ingredients
According to a pdf file for the product, 1 tablet of Neurium EHT has the following ingredients:
|Nutrient||Amount Per Serving||Percent Daily Value|
|Vitamin D (cholecalciferol)||2000 IU||500% DV|
|Vitamin B6 (pyridoxine HCL)||1.6 mg||80% DV|
|Vitamin B12 (cyanocobalamin)||10 mcg||167% DV|
|Magnesium (from 100 mg magnesium citrate)||16 mg||4% DV|
|Selenium (selenomethionine)||70 mcg||100% DV|
|Alpha lipoic acid||50 mg||N/A|
|EHT (propriotary coffee blend)||35 mg||N/A|
In the table above, “N/A” means there is no daily value for that particular nutrient.
Nerium also has the following “other ingredients” listed. I’ve put them in order as they appear on the label:
- Dicalcium phosphate
- Microcrystalline cellulose
The tablet coating of the product is composed of :
- Polyvinyl alcohol
- Titanium dioxide (color)
- Croscarmellose sodium
- Stearic acid
- Magnesium sterate
Now, let’s see if Nerium EHT – itself – has any research showing that it improves memory in people. After that, I’ll address the research on its individual ingredients.
Nerium EHT Research
I was curious as to whether the Nerium EHT supplement –itself – had been tested to see if it improved memory in humans. So I did a Google search for:
- Nerium EHT Research
- Nerium EHT Clinical Trials
I didn’t see any studies showing up.
I then went to ClinicalTrials.gov, searching for “Nerium EHT.” I did not find any clinical studies.
I then searched the website NeriumEHT.com, which also showed no research on the
I searched the Nerium.com website too. I was unable to locate any clinical trials on Neurium EHT.
Therefore, I’m forced to conclude at this time that Nerium EHT -itself – appears to have no published, peer reviewed evidence that it helps memory in humans.
That doesn’t necessarily mean it doesn’t work. Rather, it just means nobody has tested it – yet. When those studies are conducted and published I will update this review as I become aware of them.
Now, let’s look at the research on the individual ingredients in the product.
Neurium EHT Ingredient Research
From the Ingredients list above, we can see that Nerium EHT contains:
- Vitamin D 2000IU
- Vitamin B6 1.6 mg
- Vitamin B12 10 mcg
- Magnesium 16 mg
- Selenium 70 mcg
While these are all fine nutrients, for healthy people, I’m not convinced they contribute anything to helping memory, dementia or the immune system etc., over what we might get in the diet naturally or in a regular multivitamin. As such, I won’t cover them in my review.
I just don’t feel the vitamins and minerals contribute significantly to the effects of the product, although in those who are not healthy or who don’t eat well, it’s possible they might help some people.
If Nerium EHT really works, I think the answer lies with its other ingredients.
As you read the ingredients list, remember that ingredients in food/supplements are listed from the most to the least. I’m listing them in order as they appear on the Nerium EHT label.
The scientific name for this herb is Huperzia serrata. It is sometimes also called Chinese club moss or “Hup A.” Another name for Huperzine A is Selagine.
There have been several studies noting that Huperzine A may be of benefit to people with Alzeheimers disease and dementa. It might do this because Huperzine A appears to prevent the breakdown of acetycholine, (say, uh-see-tul-co-lean) a chemical involved in memory. It does this by inhibiting an enzyme (called acetylcholineesterae) that is involved in the breakdown of acetylcholine.
So, by knocking out the enzyme that breaks down acetylcholine, the levels of acetylcholine rise and the chemical stays around longer. Theoretically, this might help boost memory.
Nerium EHT does appear to contain an amount of huperzine A (50 micrograms) that has been used in clinical trials. That is encouraging. Studies show that it may take 2-8 weeks before differences are noticed. This is a general rule and I’m sure this would vary according to how bad the memory problems were, medications people take and other factors.
It should be said that not all studies show Huperzine A works. This may be due to issues involved in purifying the Huperzine A compound and extracting it from the plant. Remember, plants contain thousands of different chemicals. Huperzine A is only one of them. If the proper methods of extraction are not followed, perhaps this may be a reason for some studies showing Huperzine A doesn’t work.
Several of the studies I saw appear to come from China and while they do appear to show Huperzine A may work, at least one study notes that because of problems with how some of the studies were conducted, caution and more research is needed. WebMd.com has a nice write up on Huperzine A that includes potential side effects.
Sometimes Huperzine A is touted to improve memory in healthy people (people without memory issues). But, I can only find one study – dating back to 1999. For me, one study is not enough evidence – yet – to say healthy people need it.
Alpha Lipoic Acid
I usually see alpha lipoic acid in diabetes and weight loss supplements. There does appear to be a connection between getting diabetes / insulin resistance and getting dementia. I’ve even seen Alzheimer’s disease called “Type III diabetes” to drive this message home. Thus, adding this alpha lipoic acid to a memory supplement does, in theory, make some sense. If we can reduce blood sugar levels, we might also reduce dementia.
That said, I’m hard pressed to find evidence that alpha lipoic acid helps memory. A review of alpha lipoic acid dementia research conducted in 2001 found no good proof it helped people with memory issues.
I did locate one study noting that alpha lipoic helped, but this study had problems with how it was conducted. Also, that study used 600 mg. Nerium EHT only has 50 mg- a lot less than that study used.
When I searched Pubmed.gov (The National Library of Medicine) for the words “alpha lipoic brain,” a good amount of the research I saw involved mice and rats. That’s not to say alpha lipoic acid is useless. I do think it has some benefits. But for the brain, memory and dementia, at this point, I think we need more research to make a better judgment.
Alpha lipoic acid is also in the memory supplement Procera AVH. See that review for more information.
This is the compound that forms part of the name of the Nerium EHT supplement. EHT is a mixture of several different compounds isolated from coffee. EHT stands for “Eicosanoyl-5-HydroxyTryptamide.”
Now, you know why they call it EHT.
According to a video on Youtube , it’s said that researchers at Signum Biosciences noticed that people with severe memory decline had a disruption of a regulator protein called PP2A. The PP2A protein regulator is said to help keep the connections between brain cells “robust and healthy.”
Theoretically, anything that could help increase the PP2A, might let brain cells talk to each other better. This might help memory and other things that PP2A helps regulate.
This does sound interesting. So, is there any research on EHT?
Sigmun Biosciences had an EHT supplement called ME Sports, which was marketed to athletes. That product website – MeSports.me – redirect people to NeriumEHT.com.
They say that “ME™ sports has been shown to be beneficial in in vivo models of cognition, memory and motor function.” The phrase “in vivo” basically means conducted in animals/not in a test tube. While that’s good, its not the same thing as human studies.
On the Key References page of Signum Biosciences, they do list several clinical studies. I’m gong to link to the studies below. Let me be clear, this research is complicated. Even the titles of the studies sound complicated.
So, instead of getting bogged down in trying to explain the research (which I admit is over my head too), I’ll just list the study and give a quick breakdown as to whether it involved people, lab animals or was test tube research (which I define as research not occurring in living animals).
I think this way, people can get a better idea as to how far along the research on EHT currently is. As more research is published, I’ll update this section.
Here are the studies listed in support of the EHT compound.
- Therapeutic benefits of a component of coffee in a rat model of Alzheimer disease. (2014). This is a rat study.
- Neuroprotective and Anti-inflammatory Properties of a Coffee Component in the MPTP Model of Parkinson’s Disease. (2013). This is a mouse study.
- Enhanced phosphatase activity attenuates a-synucleinopathy in a mouse model. (2011). This is a mouse study.
- Phosphoprotein Phosphatase 2A: A Novel Drugable Target for Alzheimer’s Disease. (2011). This is a review of previous investigations.
- Protein carboxyl methylation and the biochemistry of memory. (2009). This appears to be either a review paper and / or a test tube study.
- Protein phosphatase 2A methylation: a link between elevated plasma homocysteine and Alzheimer’s Disease. (2002). This may be a test tube study that is supported by observational research on large groups of people. It proposes that increased levels of homocysteine are involved in the development of Alzheimer’s disease. The vitamins B6, B12 and Folic acid all reduce homocysteine levels. My guess is this is why these vitamins are in Nerium EHT.
- Structural mechanism of demethylation and inactivation of protein phosphatase 2A. (2008). This appears to be a test tube study.
- The Structural Basis for Tight Control of PP2A Methylation and Function by LCMT-1. (2012). This appears to be a test tube study.
- Structure of a protein phosphatase 2A holoenzyme: insights into B55-mediated Tau dephosphorylation. (2008). This appears to be a test tube study.
- Mechanisms of tau-induced neurodegeneration. (2009). This looks like a review article of past research.
- Downregulation of protein phosphatase 2A carboxyl methylation and methyltransferase may contribute to Alzheimer disease pathoge. (2004). This study involved human brain cells taken from deceased people with Alzheimer’s disease and those without Alzheimer’s disease. Even though it involved human cells, it is basically a test tube study.
- Altered expression levels of the protein phosphatase 2A ABalphaC enzyme are associated with Alzheimer disease pathology. (2004). This study involved human brain cells taken from deceased people with Alzheimer’s disease and those with out Alzheimer’s. While I can’t be sure, this study looks very similar to the study just preceding it. All the authors are the same as those in the other study.
- Tau hyperphosphorylation correlates with reduced methylation of protein phosphatase 2A. (2008). This appears to be a test tube study that involved mouse and human cells.
- Protein phosphatase 2A methyltransferase links homocysteine metabolism with tau and amyloid precursor protein regulation. (2007). This appears to be a mouse study.
- From promiscuity to precision: protein phosphatases get a makeover. (2009). This appears to be either a review of past research or a test tube study.
Please know I listed the studies like this not to slam this product or deprecate it in anyway. Rather, I wanted to make it easier for people to better understand this very complicated research. If I have missed any research studies, please let me know and I will be glad to update this portion of my review.
EHT vs. EHT 0202
As I was writing this review I came across clinical trials for an Alzheimer’s drug called “EHT 0202.” I do not think EHT 0202 is the same thing as the EHT. Here’s why I think this:
- EHT is a product of Signum Biosciences located in New Jersey. The EHT 0202 drug developed by a French company called Diaxonhit (formally called Exonhit).
- When I goggled “Signum Biosciences and Exonhit (or Diaxonhit) I didn’t see anything that made me think their compounds were the same thing.
I admit the names of both compounds are very similar. If I am wrong -and they are the same thing – can anyone can shed light on this? I’ll be glad to update this section of my review. If they are the same thing, this would alter the amount of evidence I mentioned above.
Does Nerium EHT Have Caffeine?
I think the answer is yes and no. Nerium EHT is decaffeinated but I’ve also seen it said that it has a small amount of caffeine. They say the amount of caffeine is less than is in a decaffeinated cup of coffee. That’s very little caffeine. I don’t think most people would notice it. Some people have left comments below saying that they had trouble sleeping. Whether or not this is related to caffeine, I can’t say.
Does Nerium EHT Help Concussions?
On the Sigmun Biosciences website, they have, what appears to be another EHT-containing product called “Me Sports” where “Me” stands for “Mind Enhancement.” On their website they say that Me Sports “provides the best protection for your brain.”
When I see references to sports and the brain, I think about concussions. For those who may be thinking as I do – such as athletes and the parents of athletes – I can’t say either way if it would help or not. I’m not aware of any research involving EHT and concussions. Neither Nerium or the Sigmond Biosciences websites website make any claims or references that their products would help concussions.
According to the Nerium website, the company can be reached via these phone numbers:
- USA: 855-463-7486
- Canada: 888-304-6046
- Mexico: 01-800-1NERIUM (637486)
Does It Reduce The Risk Of Dementia?
Would someone have a lower risk of dementia or Alzheimer’s or be able to keep their memory longer, if they used Nerium EHT long term? Right now, nobody can say for sure either way. Currently there is just not enough evidence to say yes or no to this question.
How To Buy Nerium
Most people purchase Nerium supplements and skin care products though a Nerium Ambassador or at the Nerium Website. While I did see Nerium supplements on Amazon, the company told me that Products on Amazon are not sold or endorsed by Nerium International and their warranty does not apply. For more on EHT, visit Nerium EHT.com.
Nerium EHT Side Effects
I believe the product is safe in healthy people. I’m not aware of any side effects from Nerium EHT at the time I wrote this review. With that in mind, here are a few things worth mentioning based on the ingredients. Speak to your doctor if you think any of this applies to you:
- Stop taking the supplement (and others too) at least 2 weeks before surgery.
- Don’t take the product if your are pregnant or breastfeeding.
- If you take ANY medications, speak to your doctor or pharmacist first.
- Remember you don’t need to make an appointment to speak to your pharmacist.
- Huperzine A might slow down heart rate. This may be a problem for people taking some types of medications, such as those for heart disease and/or high blood pressure.
- Since the product contains a little bit of caffeine, this might interfere with sleep if taken close to bedtime especially in those very sensitive to caffeine. A few people in the comments below have said they had trouble sleeping after starting the product.
Does Nerium EHT Work?
Some of the ingredients in Nerium EHT appear to make sense on paper, and some of the research I saw was very intriguing. Might the ingredients in Nerium EHT work together synergistically to improve memory and recall? While anything is possible, I think we need several human studies to know for sure.