I thought Nerium was a skin care company because until recently, everything I saw about were glowing reviews of women who said it was great for their skin and complexion. I had no idea Nerium had supplements too – until I became aware of a memory product called Nerium EHT. In this unbiased review, we will look the research on Nerium EHT and its ingredients as it pertains to improving memory. The goal with this review is to help give you an idea if Nerium EHT might be right for you. Does it really work? Let's see what we can discover. See the Prevagen review for more on that memory supplement.
What Is Nerium EHT?
From the website of the company that makes this supplement, we learn that it is “a mixture of bioactive molecules isolated from coffee that helps strengthen neural connections and promote optimal brain health.”
What does that mean?
That description is pretty vague but it sounds like Nerium EHT is supposed to help the brain work better. They used to call this a “mind enhancement formula” although that wording has since been removed from the company website. Anything that could help the brain work better, might – in theory – lead to several health benefits ranging from improved memory to protection against dementia.
We'll address some of these issues in sections below.
Nerium EHT Ingredients
According the product website (Nerium.com) a box contains a 30 day supply. Taking 1 tablet of Nerium EHT has the following ingredients:
|Nutrient||Amount Per Serving||Percent Daily Value|
|Vitamin D (cholecalciferol)||2000 IU||500% DV|
|Vitamin B6 (pyridoxine HCL)||1.6 mg||80% DV|
|Vitamin B12 (cyanocobalamin)||10 mcg||167% DV|
|Magnesium (from 100 mg magnesium citrate)||16 mg||4% DV|
|Selenium (selenomethionine)||70 mcg||100% DV|
|Alpha lipoic acid||50 mg||N/A|
|EHT (propriotary coffee blend)||35 mg||N/A|
In the table above, “N/A” means there is no daily value for that particular nutrient.
Nerium EHT also has the following “other ingredients” listed. I’ve put them in order as they appear on the label:
- Dicalcium phosphate
- Microcrystalline cellulose
The tablet coating of the product is composed of :
- Polyvinyl alcohol
- Titanium dioxide (color)
- Vanillin (extract of vanilla bean)
- Croscarmellose sodium
- Stearic acid
- Magnesium sterate
These other ingredients likely play no role in any benefits from the product.
Now, let's see if Nerium EHT – itself – has any research showing that it improves memory in people. After that, we'll look the research on its ingredients.
Nerium EHT Research
Does Nerium EHT have any proof that it really improves memory?
I was curious if it did, so I first searched Google for:
- Nerium EHT Research
- Nerium EHT Clinical Trials
No clinical studies could be located.
I then went to Pubmed.gov, which is the National Library of Medicine, a repository of millions of clinical studies. I searched Pubmed for
- “Nerium EHT”
No studies showed up.
I then went to ClinicalTrials.gov to see if there might be any studies in the pipeline that were on going
I searched for “Nerium EHT.”
No studies showed up when this review was created.
I then searched the website NeriumEHT.com.
No studies were found there either.
I searched the Nerium.com website too. I was unable to locate any clinical trials on Nerium EHT.
Summary of Search Results:
- Pubmed.gov: no published studies located
- ClinicalTrials.gov: no published studies located
- Google search: no published studies located
- Nerium.com: no published studies located
- NeriumEHT.com: no published studies located
If there are clinical research studies on Nerium EHT and memory, they cannot be found.
That doesn't necessarily mean the product doesn't work. Rather, it just means nobody has tested it – yet. When those studies are conducted and published, I will update this review as I become aware of them.
To be clear, there is research on EHT – which is part of this Nerium supplement. The research on EHT will be summarized below.
Let's look at the research on the ingredients in the Nerium EHT.
Nerium EHT Ingredient Research
From the Ingredients list above, we can see that 1 tablet of Nerium EHT contains:
- Vitamin D 2000IU
- Vitamin B6 1.6 mg
- Vitamin B12 10 mcg
- Magnesium 16 mg
- Selenium 70 mcg
While these are all fine nutrients, for healthy people, I'm not convinced they contribute anything to helping memory, dementia or the immune system etc., over what we might get in the diet naturally or in a regular multivitamin. Of course, those who are not so healthy might benefit from these nutrients, but for the most part, a multi vitamin and vitamin D supplement will cover these bases.
As such, I won't cover the vitamins or minerals in this review.
If Nerium EHT really works, I think the answer lies with its other ingredients.
Let's look at those now.
Each tablet of Nerium EHT has 50 mcg of Huperzine. The scientific name for this herb is Huperzia serrata. It is sometimes also called Chinese club moss or “Hup A.” Another name for Huperzine A is Selagine.
There have been several studies noting that Huperzine A may be of benefit to people with Alzeheimers disease and dementa. It might do this because Huperzine A appears to prevent the breakdown of acetycholine, (say, uh-see-tul-co-lean) a chemical involved in memory. It does this by inhibiting an enzyme (called acetylcholineesterae) that is involved in the breakdown of acetylcholine.
In other words, by knocking out the enzyme that breaks down acetylcholine, the levels of acetylcholine in the brain rise and the chemical stays around longer. Theoretically, this might help boost memory.
Nerium EHT does appear to contain an amount of huperzine A (50 micrograms) that has been used in clinical trials. That is encouraging. Studies show that it may take 2-8 weeks before differences are noticed. This is a general rule and I'm sure this would vary according to how bad the memory problems were, medications people take and other factors.
It should be said that not all studies show Huperzine A works. This may be due to issues involved in purifying the Huperzine A compound and extracting it from the plant. Remember, plants contain thousands of different chemicals. Huperzine A is only one of them.
If the proper methods of extraction are not followed, perhaps this may be a reason for some studies showing Huperzine A doesn't work.
Several of the studies I saw appear to come from China and while they do appear to show Huperzine A may work, at least one study notes that because of problems with how some of the studies were conducted, caution and more research is needed. WebMd.com has a nice write up on Huperzine A that includes potential side effects.
Sometimes Huperzine A is touted to improve memory in healthy people without memory problems. But, I can only find one study – dating back to 1999. For me, one study is not enough evidence – yet – to say healthy people need it.
Huperzine A has been in other memory supplements too suchas:
See those reviews for more information.
Alpha Lipoic Acid
I usually see alpha lipoic acid in diabetes and weight loss supplements. There does appear to be a connection between getting diabetes / insulin resistance and getting dementia. I've even seen Alzheimer's disease called “Type III diabetes” to drive this message home. Thus, adding this alpha lipoic acid to a memory supplement does, in theory, make some sense. If we can reduce blood sugar levels, we might also reduce dementia.
That said, I'm hard pressed to find evidence that alpha lipoic acid helps memory. A review of alpha lipoic acid dementia research conducted in 2001 found no good proof it helped people with memory issues.
I did locate one study noting that alpha lipoic helped, but this study had problems with how it was conducted. Also, that study used 600 mg. Nerium EHT only has 50 mg- a lot less than that study used.
When I searched Pubmed.gov (The National Library of Medicine) for the words “alpha lipoic brain,” a good amount of the research I saw involved mice and rats. That's not to say alpha lipoic acid is useless.
I do think it has some benefits. But for the brain, memory and dementia, at this point, I think we need more research to make a better judgment.
Alpha lipoic acid is also in the memory supplement Procera AVH. See that review for more information.
The EHT molecule is an ingredient in the Nerium EHT supplement. The EHT molecule is derived from coffee and is a mixture of several different compounds. What does EHT stand for?
Thats easy – if you can pronounce it.
EHT stands for “Eicosanoyl-5-HydroxyTryptamide.”
Now, you know why they call it EHT.
It's said that researchers at Signum Biosciences noticed that people with severe memory decline had a disruption of a regulator protein called PP2A. The PP2A protein regulator is said to help keep the connections between brain cells “robust and healthy.”
Theoretically, anything that could help increase the PP2A, might let brain cells talk to each other better. This might help memory and other things that PP2A helps regulate.
This does sound interesting. So, is there any research on EHT? Yes, there is.
Let's look at that research now.
Sigmun Biosciences had an EHT supplement called ME Sports, which was marketed to athletes. That product website – MeSports.me – redirect people to NeriumEHT.com.
They say that “ME™ sports has been shown to be beneficial in in vivo models of cognition, memory and motor function.” The phrase “in vivo” basically means conducted in animals/not in a test tube. While that's good, it's not the same thing as human studies.
On the website of Signum Biosciences, several clinical studies are listed. I’m gong to link to the studies below so you can see it as you conduct your own research. This research is complicated. Even the titles of the studies sound complicated.
So, instead of getting bogged down in trying to explain the research (which I admit is over my head too), I'll just list the study name and give a quick breakdown as to whether it involved people, lab animals or was test tube research (which I define as research not occurring in living animals).
By breaking the research down this way, people can get a better idea as to how far along the research on EHT currently is. As more research is published, I'll update this section.
Here are the studies listed in support of the EHT compound.
|Study Title||Type of Study|
|Therapeutic benefits of a component of coffee in a rat model of Alzheimer disease. (2014)||Rat study|
|Neuroprotective and anti-inflammatory properties of a coffee component in the MPTP model of Parkinson's diseasedisease. (2013)||Mouse study|
|Enhanced phosphatase activity attenuates α-synucleinopathy in a mouse model. (2011)||Mouse study|
|The structural basis for tight control of PP2A methylation and function by LCMT-1 (2011)||Test tube study|
|Phosphoprotein phosphatase 2A: a novel druggable target for Alzheimer’s disease (2011)||Review paper of previous research|
|Protein carboxyl methylation and the biochemistry of memory. (2009)||Study involving isolated cells.|
|Mechanisms of tau-induced neurodegeneration. (2009)||Review paper of previous research|
|From promiscuity to precision: protein phosphatases get a makeover. (2009)||Test tube study|
|Protein carboxyl methylation and the biochemistry of memory. (2009)||Test tube study.|
|Structural mechanism of demethylation and inactivation of protein phosphatase 2A. (2008)||Test tube study|
|Tau hyperphosphorylation correlates with reduced methylation of protein phosphatase 2A.(2008)||Test tube study of mouse and human cells|
|Structure of a protein phosphatase 2A holoenzyme: insights into B55-mediated Tau dephosphorylation. (2008)||Test tube study|
|Protein Phosphatase 2A Methyltransferase Links Homocysteine Metabolism with Tau and Amyloid Precursor Protein Regulation (2007)||Mouse study|
|Downregulation of protein phosphatase 2A carboxyl methylation and methyltransferase may contribute to Alzheimer disease pathogenesis.(2004)||Test tube study|
|Altered expression levels of the protein phosphatase 2A ABalphaC enzyme are associated with Alzheimer disease pathology. (2004)||Test tube study. Appears similar to previous study. Same authors.|
|Protein phosphatase 2A methylation: a link between elevated plasma homocysteine and Alzheimer's Disease. (2002)||Test tube study.|
As can be seen from the table above, there is a need for human research on EHT.
Please know I listed the studies like this not to slam this product or deprecate it in anyway. Rather, the goal was to make it easier for people to better understand this very complicated research. As more research becomes published, this table will be updated.
EHT vs. EHT 0202
As I was writing this review, I came across clinical trials for an Alzheimer’s drug called “EHT 0202.” I do not think EHT 0202 is the same thing as the EHT. Here’s why I say this:
- EHT is a product of Signum Biosciences located in New Jersey. The EHT 0202 drug developed by a French company called Diaxonhit (formally called Exonhit).
- When I goggled “Signum Biosciences and Exonhit (or Diaxonhit) I didn’t see anything that made me think their compounds were the same thing.
Because of this, don't confuse research on EHT0202 with Nerium EHT. I admit the names of both compounds are very similar so it's easy to confuse them.
Does Nerium EHT Have Caffeine?
I think the answer is yes and no. Nerium EHT is decaffeinated but I've also seen it said that it has a small amount of caffeine. They say the amount of caffeine is less than is in a decaffeinated cup of coffee. That's very little caffeine. I don't think most people would notice it. Some people have left comments below saying that they had trouble sleeping. Whether or not this is related to caffeine, I can't say.
Does It Reduce Dementia?
Would someone who took Nerium EHT long term (say, several years), have a lower risk of dementia or Alzheimer’s or be able to keep their memory longer? It's a tantalizing idea to be sure. Right now, nobody can say either way. Currently, there is just not enough evidence to say yes or no to this question.
For those who have dementia or are thinking about it for their family members who already have cognitive insufficiency problems, the best advice is show the the ingredients in Nerium EHT to a pharmacologist. It's worth mentioning that there is a LOT of evidence that regular exercise can preserve brain health.
Nerium EHT and Concussions?
On the Sigmun Biosciences website, they have, what appears to be another EHT-containing product called “Me Sports” where “Me” stands for “Mind Enhancement.” On their website they say that Me Sports “provides the best protection for your brain.”
When I see references to sports and the brain, I think about concussions. For those who may be thinking as I do – such as athletes and the parents of athletes – I can’t say either way if it would help or not. I’m not aware of any research involving EHT and concussions. Neither Nerium or the Sigmond Biosciences websites website make any claims or references that their products would help concussions.
Nerium EHT and Parkinsons
Given that this supplement is touted to promote optimal brain health, it would be logical to leap to the conclusion that it might help health problems associated less than optimal brain health. One such disorder is Parkinson's disease. I searched for research that might shed light on whether Nerium EHT would help Parkinson's but unfortunately could not find any.
Unfortunately, there are references to Nerium EHT as being endorsed by the Michael J. Fox Foundation. But, according to the Truth in
Advertising website, this is not true. While the The Michael J. Fox Foundation does seek a cure for Parkinsons, they do not endorse any specifics treatments.
Thanks to a reader (see comments below) I was informed that the Michael J Fox Foundation has awarded grants have been awarded to Signum Biosciences to investigate PP2A as it relates to Parkinsons.
Nerium EHT and ADHD
Given the proposed effects on brain function, one might wonder if Nerium EHT helped Attention Deficient Hyperactivity Disorder (ADHD). At this time, there does not seem to be enough evidence to say either way if it helps or doesn't. If evidence exists, it cannot be located.
Nerium EHT and Exercise
The company that invented the EHT molecule has a paper titled ” EHT® Age Defying Supplement : Scientific Rationale for Boosting Workout and Post -Workout Recovery.” This paper (which can be found by doing an online search) is not a peer-reviewed clinical study. Rather, it discusses how the ingredients in Nerium EHT might reduce inflammation that occurs after intense exercise and improve recovery.
No doubt, there is human research on the vitamins/ minerals in the product. The supplement does contain B vitamins and minerals that help the body function. The EHT molecule also might-in theory- hold promise too.
That said, whether or not Nerium EHT would benefit people who do CrossFit, Zumba, Tabata or any other intense exercise program is speculation until the research is published.
Is Nerium EHT FDA Approved?
The FDA doesn't technically “approve” supplements. This is part of the US law that regulates supplements, called DSHEA, which is short for the Dietary Supplement Health and Education Act. In the US, supplement companies do not have to tell the FDA that they are making a new supplement or get the FDAs approval before a supplement is marketed to the public.
One stipulation about the DSHEA law is that companies are supposed to notify the FDA when a supplement contains something not used before. This is called a “New Dietary Ingredient.” Since the EHT molecule is something “new,” I wonder if this would be considered a New Dietary Ingredient?
On the flip side though, since EHT is derived from coffee – something that has been around for thousands of years – maybe they do not? Either way, when I searched for “Nerium EHT FDA” and “Nerium EHT New Dietary Ingredient” I didn't see anything.
Who Makes Nerium EHT?
There are two different companies involved with this dietary supplement. The supplement, Nerium EHT, is a product of Nerium International, LLC. The EHT molecule that is in the supplement comes from another company called Signum Biosciences.
Lets look briefly look at each company separately.
According to the company website (Nerium.com), Nerium International is a “relationship marketing company.” That means they offer a variety of products which are sold via distributors, called “Nerium Brand Partners.” Basically, Nerium is a multi-level marketing company. Nothing wrong with that. The Nerium website lists their address as:
4006 Belt Line Road Addison , TX 75001. The address listed with the Better Business Bureau is a bit different than this, but in the same office building: 4004 Belt Line Rd STE 112, Addison, TX 75001-4356.
Each address corresponds to the same business center. If you Google the address you can see what it looks like.
The BBB gave Nerium International a rating of “A +” at the time I wrote this review (update. it's now not rated. See the BBB file for more information). Nerium International is has been BBB accredited business since 2014. See the BBB file for updates and more information.
Signum Biosciences is the company that discovered the EHT molecule. They are a privately held biotechnology company that is located at 133 Wall Street Princeton, NJ 08540. Their website (SignumBiosciences.com) lists this contact phone number: 732.329.6344.
According to the Nerium website, the company can be reached via these phone numbers:
- USA: 855-463-7486
- Canada: 888-304-6046
- Mexico: 01-800-1NERIUM (637486)
How To Buy Nerium
You have a few options if you want to purchase Nerium. Most people who want to purchase Nerium supplements and skin care products do so though a Nerium Ambassador. While I did see Nerium supplements and skin care products on Amazon, the company told me those are not endorsed by Nerium International and their warranty does not apply.
That doesn't mean products on Amazon are not the same thing. They looked the same to me. Nerium wants people to buy from their ambassadors. That is their business model and I'm glad they want to take care of people who sell for them.
For those who want to see what's out there for themselves:
Here's Nerium EHT on Ebay
How To Take Nerium EHT
The company website says to take 1 tablet per day with food in the morning. A box contains 30 tablets so this will last a month. The instructions also say that the supplement is best absorbed when taken with healthy fats. They probably say this because fat improves the absorption of the vitamin D -and maybe the EHT – in the supplement.
Nerium EHT Side Effects
I believe the Nerium EHT is safe in healthy people. I’m not aware of any side effects from the product at the time this review was created. There is also a lack of human research on this product as well. That said, here are a few things worth mentioning. Speak to your doctor if you think any of this applies to you. This list is not complete:
- Stop taking the supplement (and others too) at least 2 weeks before surgery.
- Don't take the product if your are pregnant or breastfeeding.
- If you take ANY medications, speak to your doctor or pharmacist first.
- Remember you don't need to make an appointment to speak to your pharmacist.
- Huperzine A might slow down heart rate. This may be a problem for people taking some types of medications, such as those for heart disease and/or high blood pressure.
- If the product contains a little bit of caffeine, this might interfere with sleep if taken close to bedtime especially in those very sensitive to caffeine. A few people in the comments below have said they had trouble sleeping after starting the product.
Does Nerium EHT Work?
While preliminary research hints that this compound (EHT), isolated from coffee, might have benefits, I think it's too soon to tell. Some of the ingredients in Nerium EHT appear to make sense on paper, but again, to know for sure, it needs to be tested in people. While I am tempted to say that if Nerium EHT really works, it's mostly because of huperzine, without proper testing, that would be speculation. Stay tuned.