Have you heard of the anti-wrinkle cream Hydroxatone? The Hydroxatone AM/PM Anti-Wrinkle Complex is said to cause a 68% decrease in fine lines and wrinkles! Impressive, but does it work? I've wanted to review Hydroxatone ever since I heard their commercial saying Hydroxatone was given away at the Emmy Awards. The name Hydroxatone is interesting and probably suggests that this anti-aging cream is supposed to hydrate and tone the skin.
If you search the Hydroxatone.com website, you'll discover that there are actually MANY Hydroxatone products. I will focus this Hydroxatone review on two of the main anti aging products:
I will do this because both of these Hydroxatone creams contain the exact same active ingredients. Those ingredients are:
- Hyaluronic Acid
Let's look at the ingredients individually and see what we can discover.
Matrixyl3000 is an invented, trademarked word used to describe a compound that is supposed to stimulate the skin to increase its production of collagen, one of the main proteins in skin. The somewhat more scientific name for this ingredient is “matrikines.”
Basically matrikines are small chains of amino acid peptides that are derived from the breakdown of larger proteins. These small peptides seem to play a role in cell division. In anti-aging creams like Hydroxatone, the hope is that Matrixyl3000 tells the skin to make more collagen and elastin, in essence helping to rejuvenate the skin. I searched the National Library of Medicine for this topic and discovered that there is some preliminary research on matrikines and skin repair. What I did not see, however, was any research proving that matrikines — added topically to the skin of humans — reduced wrinkles or fine lines on the face. They might indeed reduce wrinkles; it's just that I can't find any human proof of it.
The Hydroxatone website says that Argireline is a “Unique anti-aging peptide specifically designed to provide fast and visible results.” What they do not tell us is that Argireline is basically “botox cream.”
I know this is true because researchers actually call Argireline “botox” in research studies. Argireline is also one of the main ingredients in Principle Secret Reclaim, the anti-aging skin cream sold by actress Victoria Secret. Read that review to see the research on Argireline after you are finished here.
As an aside, I find it very interesting that neither the ads nor websites for Hydroxatone or Victoria Principle Secret Reclaim mention the botox connection when they discuss Argireline. This may be because botox is an FDA regulated drug and supplements in the US are not allowed to make direct references to how they might cure or modify any disease or condition.
Hylaruronic acid is added to many skin creams because it basically improves the hydration of the skin. So, if you could plump up the skin by increasing hydration, this might reduce wrinkles. One study did note that a hyaluronic acid gel improved the appearance of aging hands. Test tube studies also seem to show that hyaluronic acid reduces inflammation to skin cells. In theory, studies like these might indicate that adding hyaluronic acid to skin creams could be a smart idea.
Tip. Hyaluronic acid, often shows up in arthritis supplements but the evidence for it helping osteoarthritis stems from its use when it is injected —not taken as a supplement. I can't find any evidence that hyaluronic acid supplements help arthritis.
The 3 main ingredients in Hydroxatone can also be found in other products. For example, here is a product on Amazon that has the same ingredients.
The Hydroxatone website also claims that the AM/PM anti-wrinkle cream can provide defense against the sun. The sunscreen ingredients they listed are:
- Octinoxate (7.5%)
- Octocrylene (4.5%)
- Oxybenzone (3.5%)
Hydroxatone says that this has “SPF 3” which provides an SPF 15 protection against the sun. Huh? I thought “SPF 3” meant that the product had an “SPF of 3″ —not 15.
I googled “SPF 3” and could find no other product mentioning that SPF 3 resulted in a sun protection factor of 15.
I also searched for “SPF 3 = SPF 15” and didn't find anybody saying that these values were equal. So, I admit, I don't know what the makers of Hydroxatone are talking about when it comes to their sun protection factor.
It's worth noting that Cetaphil facial moisturizer has an SPF of 50 —and only costs about $15. That's a LOT less than Hydroxatone.
I could not find any published peer reviewed research on Hydroxatone products. Where is the “clinical proof” that Hydroxatone reduces fine lines and wrinkles by 68%? If that proof is out there, I can't find it. Even the Hydroxatone.com website does not list any published research on Hydroxatone.
The AM/PM Hydroxatone product does have a “clinical results” page but does not list any research there. Rather this page contains two sets of before and after pictures along with some very vague statistics that say:
100% agree Hydroxatone AM/PM Anti-Wrinkle Complex improves overall appearance of my skin.
100% agree Hydroxatone AM/PM Anti-Wrinkle Complex improves skin moisturization.
97% agree Hydroxatone AM/PM Anti-Wrinkle Complex improves my skin texture and smoothness.
97% would recommend Hydroxatone AM/PM Anti-Wrinkle Complex to their friends.
But, this does not tell us anything. For example:
- Who are these people that say Hydroxatone is so great?
- How many people were in this survey —10 people or 1,000 people?
- What were the ages of these people?
- Were they women, or both men and women?
- Where was this “clinical research” published?
Because I can't find any answers to these questions, I think their statistics are more fluff than science.
There is also a reference to a study of how “90% of women surveyed noticed a visible reduction in fine lines and wrinkles” but this is followed by the statement “based on a consumer perception study.” That's fancy talk for they asked some people if they thought Hydroxatone worked and tallied up the results. But again, they didn't publish this research. Why?
Still, if the pictures they show on the Hydroxatone.com website are untouched (and I have no reason to think they aren't), then the reduction in wrinkles is definitely noticeable. I just don't understand why Hydroxatone does not take some of that money they are obviously making on these products and do some real research.
How to contact Hydroxatone
There are a few addresses for Hydroxatone. On the Hydroxatone.com website they give this address:
PO Box 9300
Jersey City, NJ 07303
However, according to the Better Business Bureau, Hydroxatone LLC has two addresses. They are:
PO Box 1366
Hoboken, NJ 07030-1366
Phone: (201) 942-2043
302A West 12th Street # 276
New York, NY 10014
Phone: (888) 805-4271
As of 2/13/12 neither of these business locations was accredited through the Better Business Bureau. The Hydroxatone address in New Jersey had a BBB rating of “A-“ while the New York Hydroxatone address did not have a BBB rating.
According to the BBB, Hydroxatone LLC was started on 1/1/05 and a BBB file on Hydroxatone was started on 2/1/07.
While the NJ Hydroxatone address does have a BBB rating of “A-” the Better Business Bureau does list the nature of the complaints about Hydroxatone that have been filed, so look over this for more information.
Hydroxatone and the Emmy Awards
The Hydroxatone.com website mentions in a video that Hydroxatone was “given away in celebrity gift bags at this year's Emmy awards.” Why did Hydroxytone do this? It's smart marketing. You see, they gave Hydroxatone away to celebrities so that they could associate themselves with those Hollywood celebrities. This subconsciously says to all of us “if celebrities use Hydroxatone, it must be good.” But, just because they gave it away to celebrities, does not mean that those celebrities actually used Hydroxitone. Bottom line: This is just a method to market products. Don't fall for it.
Hydroxatone side effects
Does Hydroxatone have any side effects? Well, when I searched for Hydroxatone side effects, I didn't see anybody saying it did anything terrible. That said, if you search for “Argireline” —one of the ingredients in Hydroxatone —some people warn that it might cause skin sagging, due to its botox effects. I also mentioned this possibility in my review of Principle Secret Reclaim.
One small study published in 2013 titled Pilot study of topical acetyl hexapeptide-8 in the treatment for blepharospasm in patients receiving botulinum toxin therapy, noted that Argireline (they call it acetyl hexapeptide 8 in the study) extended the time between Botox treatments with no side effects.
This study is interesting but it's still difficult to say if skin sagging is real or not. I'd think it would depend on how deep —or even if —Argireline penetrated the skin, as well as how much of the face was covered with the Hydroxatone cream. Be sure to check the comments here, comments on Amazon and in my review of Principal Secrete Reclaim to see if anybody mentioned skin sagging from Argireline or any other side effects. To be even more aware, ask a dermatologist or esthetician what they think of Hydroxatone first.
Does Hydroxatone work?
I'm admittedly not an expert on skin creams and have not tried Hydroxatone. That said, if the ingredients in the Hydroxatone AM/PM cream and Hydroxatone Intensive Wrinkle cream do what they are alleged to do, then I can sort of see how these ingredients might work together to help temporarily rejuvenate skin to a more youthful appearance.
Mind you, this is a leap of speculation on my part. I have no direct proof of this other than testimonials and pictures on Hydroxatone commercials and websites. Whether Hydroxatone has an SPF of 3 or 15, it doesn't matter either way because, I think that's too little to protect the skin from aging if you are out in the sun for long periods of time. There are better ways than using Hydroxatone to prevent wrinkles from occurring in the first place. Here is Hydroxatone on Amazon for those who are interested.
What do you think?