The Grenade Thermo Detonator sounds like a weapon of mass destruction but it’s really a fat burner supplement marketed to bodybuilders and other strength athletes. Its name implies that it will explode your fat burning potential and help people quickly lose weight. Regardless of the hype, lets cut to the chase – does it really work and is it safe? In this review look primarily at the Thermo Detonator ingredients and try to find evidence for them. Along the way, my hope is to help you better determine if it’s right for you.
Thermo Detonator Research
The product website (Grenade.com) stats that the Thermo Detonator supplement
“combines scientifically researched ingredients designed to target body fat and preserve maximum lean muscle. “
Yes, several of the ingredients have been researched. We will cover some of that research below. But, ingredients -and the product – might be different.
So I wondered if anyone specifically studied the Thermo Detonator to see if it worked?
The product website did not list any research that I could see. Likewise, when I searched online, I didn’t see any clinical studies either. Therefore, I’m forced to conclude that Grenade Thermo Detonator -itself – appears to have no published peer reviewed evidence it actually works.
Because of that, the only way to know if it works is to look at its ingredients. Let’s do that now.
Thermo Detonator Ingredients
According to the label I found Amazon, each capsule of Grenade Thermo Detonator has 750 mg of these ingredients:
|Ingredient||Amount Per Serving|
|Grenade Thermo Detonator Propriotory Blend Consisting of:||775 mg|
|Green tea extract||N/A|
|Bitter orange extract||N/A|
|Grapefruit seed extract||N/A|
|Yohimbe bark extract||N/A|
|Cocoa bean extract||N/A|
|B pheneythylamine HCL||N/A|
|Yerba mate leaf||N/A|
In the table above “N/A means that there is no established daily value for the ingredient.
While they don’t tell us how much of each ingredient is present, we can estimate this by remembering that ingredients listed at the top likely make up most of the product while ingredients listed toward the bottom, are present in the least amount.
Please know the chemistry of each ingredient in this list is very complex. As such, I’m not going to bog you down with it. Instead, I’ll try to locate human evidence for each ingredient because evidence in people is what’s most important to people.
Green Tea Extract
The product website tells us that the green tea extract contains “80% polyphenols, epigallocatechin gallate and 45% epicatechin.” So what’s all that mean? Well, epigallocatechin gallate is also called EGCG. It’s a polyphenol in green tea. A polyphenol is a type of phyto-nutrient. Epicatechin is a type of flavonoid in green tea. Flavonoids are another class of phyto-nutrient.
So, what’s the evidence that green tea helps people lose weight?
When you look at individual studies, they are all over the place with some saying green tea might work and others saying it might not work. That said, when researchers look at all the studies together (called a meta-analysis), they tend to find that it might not work so well.
For example, in this 2012 review of previous green tea clinical trials, the researchers concluded that the weight loss effects of green tea were small and not clinically important. In this 2014 review, the researchers came to the same conclusion. Green tea didn’t work.
Green tea is controversial when it comes to liver health. See the side effects section below for more info.
Bitter Orange Extract
The product label tells us that the bitter orange extracts used are:
Let’s address each of these one at a time
This compound “looks” like ephedra, which was a popular fat burner herb until it was banned in the US in the early 2000’s after several people died from overdosing on it.
The idea is that since synephrine (which is also called citrus aurantium) looks like ephedra, it might work like ephedra. It sounds plausible but not all studies show it works. Some find it works and others find it doesn’t work.
I think one problem with this dependency is that there are different types of synephrine. It might be possible that not all types work the same way. For example, this study notes the differences between para synepherine and meta synephrine. The makers of Grenade don’t tell us what version they are using.
In addition, many weight loss studies combine synephrine with other ingredients. This leaves open the possibility that any weight loss attributed to synephrine might be due to something else or a combination of ingredients.
To be honest, until better studies are done, I’m not prepared to say synephrine works or doesn’t at this time.
This is a metabolite of synepherine. I think the idea here is that if its related to synephrine and looks like synephrine, that it might augment the effects of synephrine. Maybe it does or doesn’t. When I searched the National Library of Medicine for ” “octopamine weight loss,” I saw some rat studies but nothing involving people.
This is another compound related to synephrine and hordenine (discussed below). When I searched for evidence that N-Methyltyramine caused weight loss in humans, I saw no studies.
This is an amino acid that’s involved in the production of synephrine and the other synephrine-related compounds. My guess is the thinking is that “more tyramine=more synephrine and syephrine-like compounds” in the hopes that all of these will promote greater weight loss and fat burning. It’s an interesting theory but I can’t find any evidence for it.
Also called hordeum but in supplements, it’s usually called “hordenine.” It’s chemically related to N-Methyltyramine and hence tyramine – and therefore also synephrine. I am unable to find any peer reviewed human studies showing hordenine helps people lose weight. A supplement I’ve previously looked at that also contained hordenine is:
See that for additional information on hordenine.
This is just another name for caffeine. The stimulation effects of caffeine is well known and it’s a very common ingredient in fat burners and pre-workout supplements.
Grapefruit Seed Extract
I can’t tell what extract of grapefruit seeds is used in Thermo Detonator. While I don’t see grapefruit used in many weight loss supplements, I understand the logic. Grapefruit is thought to slow down the clearance of caffeine. Theoretically this might mean the stimulation effects of caffeine (and maybe other stimulants) might stay in the body longer, resulting in greater effects (and side effects).
When I looked at the Jillian Michael’s Maximum Strength Fat Burner, it also had grapefruit, so see that review for more insights. ha
Grapefruit seeds do contain an extract called Naringin. While I can’t know if this is the extract used in the Thermo Detonator, I have seen naringin in fat burners before.
Ironically, in this study from 2006, naringin actually prevented the increase in metabolism in humans brought on by caffeine. Naringin also had no effect on fat burning. How relevant this is, I can’t say because again, I don’t know what extract of grapefruit seed is being used.
Capsaicum the ingredient in chilli peppers that makes them hot. The idea with adding capsicum to fat burners is that they will heat up metabolic rate, causing us to burn more fat.
So, whats the evidence for it? Well, is this review of chili pepper and weight loss, researchers noted that daily use of at least 2mg of capsaicinoids (compounds in chilli peppers) was associated with eating fewer calories. This study however, did not show weight loss, but rather, only that chilli peppers (and presumably capsicum) might help curb appetite.
In this 2012 review of previous chili pepper and weight loss studies, researchers estimated that consuming capsaicinoids daily might increase metabolism by about 50 calories per day. This, they said would promote clinically significant weight loss results after about 1-2 years of use. These results appear to be supported by this 2012 study of capsicum and weight loss. These researchers noted that while capsaicin might work, its effects are likely small.
This is an compound derived from the fruit of of the Evodia tree that grows in Asia. In a 2001 study performed in mice, evodiamine caused the mice to lose more fat than those which didn’t get evodiamine after 12 days of use.
In a 2014 study, lab rats given evodiamine gained less weight than rats not getting evodiamine. Evodiamine, was also shown to increase a fat burning enzyme called hormone sensitive lipase in both fat cells and liver cells of lab mice.
This is all very interesting but I have to ask the question, where is the human research? It’s not like evodiamine is something new; its been studied at least since 2001. Does it have the same effect in people? I don’t know.
Yohimbe Bark Extract
They don’t tell us what extract of yohimbe is in Grenade Thermo Detonator. That said, there is some research on yohimbe (also called yohimbine) to warrant its use in a weight loss supplement.
In a 2006 study involving 20 soccer players. In this study, the players were given 20 mg of yohimbe for 3 weeks or a placebo. While yohimbe did not improve the soccer players exercise ability, it was shown to reduce body mass and fat mass compared to those getting the placebo.
Other than this study, I’m hard pressed to find more human research. Yohimbe is not without cautions as is evidenced by this 2010 review citing a number of adverse drug events (side effects) reported to the California Poison Control System.
Yohimbe is sometimes used as an ingredient in such as sexual performance supplements. See my review of Androzine for more insights on yohimbe.
This stuff sky-rocked to fame after being featured on the Dr. Oz show, however as I revealed in my review of respberry ketones, the evidence for this “miracle in a bottle to burn your fat” (as Dr. Oz put it) was based on just 2 mouse studies.
Raspberry ketones is over hyped and under researched for its effects on human weight loss.
Just as double check, I looked again to see if there was human research on this ingredient. I still can’t find any. Even the “evidence” the Grenade website touts as proof of the weight loss effects for raspberry ketones is a mouse study. Here’s the study.
So why is it in Grenade Thermo Detonator?
This is an amino acid. There are two possibilities that I can think of for why Thermo Detonator might contain phenylananie.
One reason may be due to some research hinting that phenylalanine might stimulate the release of a hormone called CCK which reduces appetite. But, this research involved isolated cells rather than human beings.
The Grenade website does list a a small study phenylalanine stimulating CCK in people. The study found that phenylalanine ramped up CCK and caused people to eat fewer calories. One problem however is that that study gave people 10,000 mg (10 grams) of phenylalanine. That’s a LOT more than is in the Thermo Detonator. Would less do the same thing? Maybe. I don’t know.
Another thought as to why this amino present might be because of a downstream metabolite of phenylalanine called phenylethylamine (say “Fee-nil-ethyl-A-mean”) or its more common name, “PEA.” As I mentioned in my review of Saba Ace (a weight loss supplement), PEA “looks” like stimulants called amphetamines.
Either way, without direct human studies, it’s difficult to know how much of a weight loss effect this amino acid might have.
Cocoa Bean Extract
What extract are they using? They don’t tell us. Could the “extract” be caffeine.
B pheneythylamine HCL
This is pheneythylamine (PEA), the downstream metabolite of phenylalanine I mentioned above. It has stimulant like effects although how well it works in people needs better study.
This has been a popular weight loss supplement for a long time. It’s so popular that I have an entire coleus forskohlii review where you can read the weight loss research.
Most of the research I have seen involves a specific brand called ForsLean. The studies so far are divided in that some say it might work and others saying it might not work.
Yerba Mate Leaf
In a 2014 study of yerba mate and exercise, 14 people were given either 1000 mg of yerba mate or a placebo. Those getting yerba mate appeared to be better at burning fat during exercise than when they were given the placebo.
I’ll point out that 1000 mg is more than all the ingredients in Thermo Detonator combined.
Most of the other studies I see on yerba mate involve either lab rats or lab mice.
DMAE is short for dimethylaminoethanol (die-methel-amino-ethanol).
I originally ran into DMAE when I was writing my book. It used to also go by its drug name, Deanol.
My guess as to why DMEA is in this supplement may be due to its ability to increase acetylcholine levels – and that this might help some people with memory issues. Might this also increase the focus and concentration of those involved in heavy weight lifting? I’m taking wild guess on this. It’s pure speculation on my part.
If you are healthy, your acetylcholine levels are fine. DMEA is at the bottom of the ingredients list so that likely means Thermo Detonator has very little of it.
Ingredients That Are Stimulants
Here are the ingredients in Grenade Thermo Detonator that I believe are stimulants:
- Green tea (if it has caffeine)
- Tyramine (maybe)
- cocoa bean extract (if the extract is caffeine)
- Pheneythylamine (maybe)
How Much Caffeine Does It Have?
I’m not sure how much caffeine is in Thermo Detonator. If anyone knows let me know and I’ll update this part of my review.
Ingredients With Evidence
Which of the ingredients in the Thermo Detonator have human clinical weight loss evidence? Based on the studies I’ve seen, these are the ingredients:
- Coleus Forskohlii (read the review)
- Green Tea (it’s debatable though)
- Yerba mate
Notice I did not list caffeine. Even though its popular in weight loss products, and has a mild fat burning effect, the caffeine /weight loss studies I’ve seen combine it with other things like ephedra.
Who Makes Thermo Detonator?
The company is called Grenade LLC and it is company based in the United Kingdom. According to Whois.com it is located in the Coventry Business Park at 5 Spitfire Close West Midlands CV5 6UR.
Their website also lists this address in the US: 225 Episcopal Road, Berlin, CT 06037. If you google this address, you’ll see several businesses showing up. One of those is called Sportika (Sportika.com). This is a company that helps other companies do business.
The product webiste lists this phone number for UK residents: +44 (0) 2476 711 284
I was unable to find a contact phone number for people in the USA although the product website does have a form to submit an email.
Thermo Detonator Side Effects
I really appreciated that the Grenade company listed several warnings to to people about this supplement. I’m going to list those warnings here and then I’ll mention some other things below. READ THIS LIST CAREFULLY:
1. Grenade is not to be used by persons under age 21
2. DO NOT USE if pregnant or nursing
3. Never exceed the recommended maximum dosage
4. DO NOT consume caffeine, synephrine or thyroid boosting compounds from other sources including but not limited to coffee, tea, soda and other dietary supplements or medications containing phenylephrine or caffeine or any other stimulants whatsoever.
5. Grenade contains caffeine
6. DO NOT USE this product for longer than 8 weeks and make sure that usage is followed by a 4 week “off period.”
7. Consult your doctor before using if you are taking medications including but not limited to MAO inhibitors, anti-depressants, aspirin, non-steroidal anti-inflammatory drugs or products containing phenylephrine, ephrine, pseudoephedrine, phenylethylamine or other stimulants.
8. Consult your doctor prior to use if you have a medical condition including but not limited to heart, liver kidney or thyroid disease, psychiatric or epileptic disorders, difficulty urinating, diabetes, high blood pressure, heart arrhythmia, recurrent headaches, enlarged prostate or glaucoma.
9. Discontinue use 2 weeks before surgery.
10. Immediately discontinue use if you experience dizziness, severe headaches, rapid heartbeat or shortness of breath
11. Note for tested Athletes. consult your specific athletic federation prior to use.
To add to this list,
- There is speculation that green tea may be implicated in liver problems and liver failure. This might happen even in young, healthy people.
- Grapefruit might interfere with MANY medications. It might speedup the breakdown of some medications from the body and slow down the breakdown of others. If you take ANY medications, show the ingredients to your pharmacist/doctor.
- As I outlined in my book about rhabdo, fat burner supplements have caused rhabdomyolysis in some people. I’m not aware of rhabdo happening with this particular product, but it’s something to keep in mind, especially if you are engaging in high intensity exercise.
- Yerba mate has been linked to some types of cancer. Much of the evidence implicates herba mate tea. I’m not sure about herba mate supplements.
- This product is not for teenagers. Even young, seemingly healthy teenagers might have side effects like those the maker of the product outlined above. Read this for more information
- Supplements containing synephrine have been associated with heart problems even in young people.
- If you are an athlete and get drug tested, show the list of ingredients not just to your coach, but to also whoever is in charge of your sports drug testing. See what they say before you use this supplement.
- It’s possible your heart will start racing when you take this product. Racing hearts rates does not mean you are burning fat.
If you have ANY health issues, show the ingredient list to your pharmacist and specifically ask them if its safe for YOU to use. There are many ingredients in Grenade Thermo Detonator and they may interact with medications you take or health issues you have.
Does It Work?
Grenade Thermo Detonator has no peer reviewed clinical studies in humans to show it works in humans. So, I can’t say for sure if it works or doesn’t. I didn’t try it so I can’t speak to how people will react if they try it. Judging from the comments I saw on Amazon, it seems to work in some but not others. Some people there reported side effects that I found disturbing.
There are a lot of comments on Amazon by people who have tried it.
If you used it and it worked for you great. I’m happy for you. My opinion though is to bypass this stuff.