Do you have trouble remembering names? Do you forget where you put things? Are you loosing your mental edge at work? These are some of the questions asked as I watched an infomercial for Cebria, a memory supplement. The TV infomercial is interesting and noted that Cebria has a clinical study to back it up too. So, does Cebria work? Let's look at the ingredients and evidence and see what we can discover.
What Is Cebria?
Cebria is a dietary supplement touted to “improve short term memory” and to help people “think faster and remember more” in “just 30 days.” Cebria contains different ingredients than other memory supplements I've looked at previously such as:
See those reviews for more information on those memory supplements. Cebria is also said to be backed by a clinical study, which I'll look at below.
According to Cebria.com, each capsule contains the following ingredients:
|Neuro Pep 12 Proprietary Blend||282.8 mg|
|Composed of the following:|
Basically, this list tells us that there is only one active compound in Cebria (which they call “Neuro-Pep-12″). That compound, in turn, is composed of 15 other ingredients, most of which are amino acids.
While they don't tell us the amount of each of the ingredients that make up Neuro-Pep-12, they are listed in order. As such, we can guess that the those at the top of the list comprise the most of the Neuro-Pep-12 proprietary blend and those at the bottom, make up the least.
Cebria also contains these other ingredients that likely play no role in its effectiveness:
- Magnesium stearate
- Silicon dioxide
As an aside, I wondered why Neuro Pep 12 contained the number “12” since it's made up of 15 separate ingredients. If anyone knows, leave a comment below and I'll be happy to update this part of my review.
From Cebria on Amazon, I also learned that there is also an “Ultra Cebria” where each capsule has 445.3 mg of Neuro Pep blend. That Ultra blend also contains vitamins B6, folic acid and vitamin B12.
I speculate that these vitamins were included because of their ability to reduce homocysteine, compound that may be linked to dementia. Either way, none of these vitamins were used in the research on Cebria (Neuro-Pep-12) that will be received below. Whether or not they add anything to the effects of Neuro-Pep-12, I cannot say. I'm also not aware of any studies that compare “regular” Cebria to Ultra Cebria.
What is Neuro Pep 12?
Before we get into the Cebria clinical trial, it's worth understating something about its active compound, which they call Neuro-Pep-12. In the studies, it's actually called N-Pep-12.
This compound, is derived from something else called, Cerebrolysin. Like N-pep 12, Cerebrolysin is also a mixture of various amino acids. According to the the Chchrane website, Cerebrolysin is derived from pig brains.
Both Neuro-Pep-12 and Cerebrolysin are sometimes called “Nootropics.” This is a word used to describe how something has a positive effect on the memory and other brain functions. I wanted to bring this up in case you run into this word during your own research.
There have been some studies which find Cerebrolysin can help people with mild to moderate dementia. One problem with Cerebrolysin however is that it has to be given by injection. N-pep-12 (Neuro-Pep-12) – which is derived from Cerebrolysin – can be taken orally.
There is a patent on the compound in which Cebria is based. Here is the link to the patent. While the patent does not specifically mention Cebria by name, it does describe a supplement that appears to bear a strong resemblance to it. I'll assume that the compound described in the patent has the same ingredients and concentration as Cebria does.
If you saw the Cebria TV infomercial, you may have noticed that they also mentioned a clinical study. Let's talk about that now. The study is titled “Effects of N-PEP-12 on memory among older adults.” It was published in 2005 in a journal called International Clinical Psycopharmacology. Remember that N-Pep-12 is another name for Neuro-Pep-12.
If you do an online search, you can find a PDF of the study. Here is a brief summary of the study and its results:
- The study lasted 30 days and involved 54 men and women over age 50.
- The average age of the people was 68 years of age. Most of the people in the study were women.
- None of the people had dementia and were deemed basically healthy.
- The people were broken up into two groups: the placebo group and the N-Pep-12 group (treatment group). Interestingly, there were more people in the N-pep-12 group (36 people) than the placebo group (18 people).
- The people in the study were given a series of memory tests before and 30 days later.
Results: The researchers noted that those getting N-Pep-12 performed better on some of the memory tests than those getting the placebo after 30 days.
Normally, studies have equal or near equal numbers of people in the placebo group and treatment group. In this study, there were twice as many people getting N-Pep-12 as getting the placebo (36 vs. 18).
Some researchers have advised caution when it comes to studies that have unequal numbers of people in the placebo group and treatment group. This may be a fine study but I would like to see one or two more human clinical trials having equal numbers of people before passing judgement.
Other Cebria Studies
I searched the National Library of Medicine (PubMed.gov) for “N-pep-12” and located these other clinical trials on this compound:
This study is titled N-PEP-12–a novel peptide compound that protects cortical neurons in culture against different age and disease associated lesions. This is a study of chicken brain cells which noted that N-Pep-12 prevented brain cell death during aging and when the cells were subjected to various insults like trauma.
This study is titled, Neuropeptide dietary supplement N-PEP-12 enhances cognitive function and activates brain bioelectrical activity in healthy elderly subjects. This study involved 6 people older than 50 years of age (51-76 age range). These people were given 180 mg of N-Pep-12. After 6 hours, the brains of the people showed differences in some of their brain waves and the people performed better on memory tests. There was no placebo group in this study. All the people received N-Pep-12 and I presume they all knew it was a memory supplement they were taking.
This study is titled Long-term treatment of aged Long Evans rats with a dietary supplement containing neuroprotective peptides (N-PEP-12) to prevent brain aging: effects of three months daily treatment by oral gavage.
This study involved rats that were randomly given either N-pep-12 or a placebo for 3 months. Rats treated with N-Pep-12, appeared to show improvements memory compared to rats which got a placebo. The brains of rats getting N-Pep-12 also show some positive physical changes compared to the other rats too.
These were the only studies I was able to locate when I wrote this review. Herbert Moessler, one of the inventors of N-Pep-12 appears on all of the studies above. That is not necessarily a bad thing. I appreciate it when companies and researchers invest time into researching their product.
That said, what I found odd was that in 2005 two human studies were published, yet in 2015, a rat study was published. Why? Over the course of a decade, why are there not more human studies on N-Pep-12?
Who Makes Cebria?
I'm always interested in the makers of dietary supplements so let's take a brief look at the makers of Cebria. The product website (Cebria.com) says the name of the company is Cebria LLC. According to their Better Business Bureau file, they are located at 14724 Ventura Blvd Fl 200, Sherman Oaks, CA 91403-3514. If you google this address, you can see that there is a large office building at this location. Looking at the Google results shows many other businesses at this same address.
I'll also point out that this is also the address listed for Prosvent, a prostate supplement I previously reviewed. Either way you look at it, I don't think this office building is where Cebria, Prosvent or other supplements are made.
When I wrote this review the Better Business Bureau gave Cebria LLC a rating of “A+.” See the BBB file for updates and more information.
Cebria LLC is related to another company called TheraBotanics LLC, which is mentioned in the Cebria TV infomercial. I can't find a website for TheraBotanics, but according to this article from Forbs.com, it appears its parent company is called Ideal Living (IdealLiving.com), which seems to be a advertising/marketing company. The BBB gives Ideal Living a rating of “A+.“ See their BBB file for updates and more information.
Having said all that, the Cebria infomercial also tells that the maker of Cebria is a company called Ever-Neuro Pharma which is located in Austria. Their website is EeverPharma.com.
Two other companies I turned up related to N-Pep-12 are Xedition Pharmaceuticals and EBEWE Pharma. I'm not sure of the relationship between Ever-Neuro, Xedition pharma and EBEWE Pharma.
On the Ever-Neuro Pharma website, they have a supplement called MemoProve. That product contains an ingredient they call “N Pep 12” which I take to be the same thing as Neuro Pep 12 in Cebria. Could MemoProve be the European version of Cebria?
How To Contact Cebria
Who is Dr Marcus Laux, ND
The product website calls Dr. Laux is the spokesperson for Cebria. He is a naturpathic doctor and has authored several books.
Who is Bella Shaw?
Bella Shaw is the host of the Cebria Infomercial. According to the Internet Movie Database, she has a BA in journalism and appeared in several movies and TV shows.
How To Take Cebria?
The product website says that Cebria is to be taken in the morning with water or another liquid. They dont mention whether or not to take it on an empty stomach or with food.
Does Cebria help Alzheimers?
Cebria appears to be marketed to people over the age of 40 who have age-related memory loss. There is currently no published peer reviewed evidence it that Cebria helps people who have Alzheimer's disease or other forms of dementia.
Cebria Side Effects
Currently the research does not show any significant side effects from taking the ingredients in Cebria. Cebria does have lactose which may be a problem for those who are lactose intolerant. Women who are pregnant or breastfeeding should speak to their doctor first. The same thing goes for anyone who is about to have surgery.
As I wrote this review, the human research does not show what happens after 30 days of use. While I'll always advise those who take any medications to speak to their doctor or pharmacist first, I believe if your healthy, Cebria is safe.
Does Cebria Work?
I'm on the fence at this point. The research on Cebria's ingredients is interesting although I wish there was a few more human studies to better understand how well it might benefit people. The good news is if it works – or doesn't – you should know in 30 days.
Here is Cebria on Amazon if you want to see what others are saying.