Anatabloc Anti-Inflammation Joint Supplement: Review of Clinical Evidence

by Joe Cannon on January 8, 2013

Have you heard of Anatabloc? It’s an anti-inflammatory supplement sold at GNC and elsewhere, touted for joint support and to reduce chronic inflammation. I first heard of Anatabloc when a friend bought it from GNC for some knee pain. I was intrigued because Anatabloc didn’t seem to be the same as other arthritis supplements. Does Anatabloc really work? What follows is my review of the research in support of Anatabloc and the company that makes it. FYI, as you do your own research, keep in mind that while some people call it “Anatablock” online the product is really spelled Anatabloc.

 

What is Anatabine?

Before we delve into Anatabloc, I need to tell you about Anatabine (also called anatabine citrate). Anatabine is said to be the active ingredient in Anatabloc. It is a chemical that is found naturally in egg plants, potatoes, green tomatoes and other members of the Solanaceae family of plants as well as tobacco and tobacco smoke.

Anatabine “looks” like nicotine chemically, and is also used some anti-smoking supplements. Anatabine has a longer half life than nicotine, so it stays in the body longer, which is the reason it’s being looked at to help people quit smoking. For more info, see the anatabine Wikipedia page.

 

How does Anatabloc work?

According to the product website (anatabloc.com), these are the basics behind how Anatabloc is supposed to reduce chronic inflammation:

 

1. Anatabine enters the cells of the body where it…Anatabloc

 

2. Deactivates a protein called NFkB.

 

3. When NFkB is deactivated, it can’t enter the nucleus of the cell (the brain center of the cell) and thus, can’t cause excessive cellular inflammation. As such, chronic cellular inflammation is said to be decreased.

 

If Anatabloc really does reduce cellular inflammation, theoretically it may help conditions such as Alzheimer’s disease, arthritis and heart disease, which are linked to chronic inflammation.

 

Anatabloc ingredients

According to Anatabloc.com, Anatabloc contains these ingredients

Anatabine 1 mg
Vitamin A 500 IU
Vitamin D3 40 IU

 

I want to focus only on Anatabine for this review because this is said to be the “secret sauce” in Anatabloc. Also, I’m not aware of any research that combined all three of these ingredients, so it’s hard to tell if they add anything to the effects.

 

Anatabloc Research

On “The Science” page of the Anatabloc website (Anatabloc.com) it’s stated that ” Anatabloc® has been shown in pre-clinical tests to assist in maintaining healthy levels of c-reactive protein, indicating that it helps provide anti-inflammatory support.”

The big word in this sentence is “pre-clinical.” For me, the word pre-clinical is fancy talk, meaning that there is not much peer-reviewed proof.

 

The website does say “Anatabloc® has been shown to have significant anti-inflammatory effects in-vitro, in animal studies, and in human epidemiological studies” and that….” A clinical trial using Anatabloc® is ongoing. Two additional trials will get underway by year-end.”

 

Translation: Test tube studies and lab animal studies seem to support Anatabloc as well as one study of a population of people. That isn’t the best of evidence in my book, but it is something.

 

There is a page on the Anatabloc site called “For Healthcare Professionals” that is supposed to help doctors better understand Anatabloc. However, that page is blocked to everybody who is not a licensed healthcare professional. That includes me.

 

I didn’t like that that they would not show me their proof, but no worries. Any research published on Anatabloc will be found in the National Library of Medicine. So, what I want to do now is summarize the research I could find on Anatabloc and Anatabine.

 

When I searched the National Library of Medicine specifically for “Anatabloc” I was unable to locate any research studies. So, the product Anatabloc itself seems to have no proof.

Next, I searched for “Anatabine.” Now, I found some research. Here is a summary of the inflammation-related research on anatabine that I discovered.

 

1. In a study titled “Anatabine ameliorates experimental autoimmune thyroiditis” published in 2012 in the journal Endocrinology, anatabine reduced the inflammation of the thyroid gland in female mice.

 

2. In another mouse study published in 2011 in the European Journal of Pharmacology, titled “Anatabine lowers Alzheimer’s Aβ production in vitro and in vivo”, anatabine was shown to reduce proteins indicative of Alzheimer’s disease as well as a protein called NFkb.

 

While I could not read the entire study, others online also say that this investigation also noted reduced levels of C reactive protein (CRP), a marker of inflammation.

 

This is the study behind the online hype that Anatabine (Anatabloc) might be a cure for Alzheimer’s disease. It’s a mouse study! No study —yet —has shown that Anatabine (or Anatabloc) improves Alzheimer’s symptoms in people.

 

3. In 2013, a mouse study titled Amelioration of Experimental Autoimmune Encephalomyelitis by Anatabine was published in the journal PLOS One. In this study 29 mice were injected with a chemical that basically created a “mouse version of multiple sclerosis” called experimental autoimmune encephalomyelitis (EAE).

Since EAE is similar to MS, researchers study EAE in animals to see how multiple sclerosis works in humans.

The mice were then randomly given a placobo (water) or anatabine in water. The amount of anatabine used was 20 mg per kilogram of body weight for 16 days.

 

At the end of the study, researchers noted that treatment with anatabine “delayed the onset of EAE” and mice had a “decreased severity of neurological defects.” Based on this, researchers speculated that anatabine might offer some help to people with multiple sclerosis.

 

While this is a very interesting investigation, it does not prove anatabloc helps people with MS. It might but I just don’t know. I wonder what would happen if Anatabloc were randomly given to 100 or so people with MS to see what happens after several weeks. I hoping somebody does this study soon.

As an aside, I’ll mention that there is also some MS research on a supplement called Protandim, so see that review for additional information.

 

4. Another study, published in 2013, in the European Journal of Pharmacology was titled “Anti-inflammatory activity of anatabine via inhibition of STAT3 phosphorylation.” This was a mouse study too.

 

In 2013, a study was published in the FASEB Journal titled, Anatabine Significantly Decreases Nicotine Self- Administration. This study used 4 rhesus monkeys. Monkeys were given injections of saline (as a control treatment) or injections anatabine about 15 minutes before they had access to food or nicotine. The researchers wanted to see if anatabine was able to reduce the monkey’s craving for food or nicotine. The researchers noted that anatabine significantly reduced the monkeys craving for nicotine, but had no significant effect on food intake. The saline treatment had no effects on either nicotine or food.

These 5 studies  appear to be the  only published research on Anatabine currently available.  I could not find any human research of anatabine reducing chronic inflammation in people.  I will update this list as more research is published.

Note. I also could not locate the “epidemiological study” that the Anatabloc website says was conducted.

It’s possible that there is more research on the Anatabloc science page, but since that page is blocked to everyone but licensed health care professionals, I can’t access it.

 

As far as I can tell, Anatabloc appears to be marketed primarily to people with arthritis and joint pain.  Anatabloc TV commercials even say  it’s “scientifically proven to help regulate excess inflammation in joints and muscles.”  If that’s so, why can’t  I find any arthritis or joint pain research on Anatabloc or anatabine? 

 

Summary of Anatabloc research

Let’s now summarize the published research studies I was able to locate about Anatabine/Anatabloc.

 

So, given these 4 mouse studies and 1 monkey study, I have to ask the questions:

  • Where is the human research on Anatabloc?
  • Where is the human arthritis research on Anatabloc?

 

As reported by Reuters, there is a human trial of Anatabloc that is in the beginning stages. It is tentatively called “A Three Month, Single-Site or Multi-Site, Double-Blind, Randomized, Placebo-Controlled, Parallel-Group Trial to Evaluate the Safety, Tolerability and Potential Effects of the Dietary Supplement Anatabine in Subjects with Alzheimer’s Disease.”

When this trial is completed and published I will update this review with that new information.

 

So, for the moment it seems to me that the primary evidence for Anatabloc is 4 mouse studies. Still, the finding that anatabine appears to reduce inflammation —in mice —is intriguing. I was particularly interested in the work showing that anatabine reduced thyroid damage. Might this one day help people with hypothyroidism? It’s a question I’d like to see addressed in future studies. Right now there is no proof that Anatabloc helps people with hypothyroidism.

 

Who makes Anatabloc?

This is where things get a little complicated. It’s said that Anatabloc is produced by a company called “Rock Creek Pharmaceuticals.” With an impressive name like that, you’d think this was a big pharmaceutical company like Merck or Pfizer. That’s what I thought. But, I couldn’t find a website for Rock Creek Pharmaceuticals.

I found this strange.

When I went to the Anatabloc website (Anatabloc.com), I saw that they don’t list an address for Rock Creek Pharmaceuticals. They do however give a number to call and order Anatabloc : 800-778-2031.

 

So I called this number, and discovered that it’s not the phone number for Rock Creek Pharmaceuticals. Rather, this number takes you to a call center in Michigan where people can order Anatabloc. I wanted to know where Rock Creek Pharmaceuticals was located, but the person I spoke with could not tell me. He did refer me to another call center number (800 391 9164) which is the customer service call center, located in Lansing Michigan.

 

The  person I spoke with at this call center told me that Rock Creek Pharmaceuticals is located at 181 Marsh Hill Road Orange CT 06477. The link I’ve provided shows what this address looks like. It’s a highway. I only saw a house in the distance. Other than that, I saw nothing but highway and trees.

 

So, I then checked the Better Business Bureau website for Rock Creek Pharmaceuticals and discovered yet another address. The address the BBB has is 4470 Cox Rd Ste 110, Glen Allen, VA 23060. This address is a parking lot adjacent to a large building.

 

According to Google, several businesses are located at this address, including Star Tobacco Inc. This is important, because if you Google Rock Creek Pharmaceuticals, one of the websites that comes up is Star Scientific.

 

It turns out that Star Scientific and Rock Creek Pharmaceuticals are the same company! Star Tobacco Inc. is a subsidiary of Star Scientific —as is Rock Creek Pharmaceuticals. This make sense because Anatabine— the main ingredient in Anatabloc —is also found in tobacco.

 

Star Scientific is a publicly traded company. Its stock symbol is STSI. Star Scientific works to reduce the damage from smoking tobacco. In other words, part of their work is to try to make a “healthier” form of tobacco.

 

According to a 2012 blurb about Star Tobacco in Bloomberg Business Week, Star Tobacco lists yet another address of 801 Liberty Way Chester, VA 23836. According to Loopnet.com this is a distribution center. I’m guessing this might be where they ship Anatabloc from?

The customer service person I spoke with told me that Star Scientific does the actual science on Anatabloc, while Rock Creek Pharmaceuticals is the maker and distribution center for the product.

 

Since Star Scientific works with tobacco, I can only guess that they chose the clean, wholesome-sounding name, Rock Creek Pharmaceuticals, to distance themselves from the negative association people usually have of tobacco products.

 

Update. As reported in the Winston-Salem Journal on 12/17/12, Star Scientific is getting out of the tobacco business to focus on development of Anatabloc and other health and wellness products. The reasons for the change are cited as being due to US tobacco regulations and the “negative impact” of having a company in the tobacco business at getting researchers interested in investigating anatabine as a product to reduce excessive inflammation.

The journal also cites that Star Scientific’s association with GNC puts their product within reach of most people in the US, given that there is a GNC within 5 or less miles of 95% of all Americans.

Anatabloc and John Isner

As is reported on the Sports Pro Media website on Jan 7 2013, American tennis star John Isner has partnered with Star Scientific, after the Association of Tennis Professionals (ATP) relaxed its rules about players wearing corporate logos during tennis matches. Sports Pro Media says that John Isner was the first tennis player to capitalize on the new relaxed rules.

The website quotes John Isner, who was already using Anatabloc, as saying:

” Anatabloc has allowed me to stay on the court longer and in the gym longer, while at the same time helping with the recovery process. I simply do not feel as sore and fatigued as I have in the past.”

 

Based on these statements, I predict that various websites —and day traders of Star Scientific stock —will be making references that Anatabloc improves exercise performance and recovery from exercise.

 

To that I say, just show me the research. Having looked at all of the Anatabloc research, I can say categorically that there are no published exercise studies on Anatabloc right now. The same is true for Anatabloc and muscle soreness also. Likewise, there is no evidence either way that Anatabloc improves aerobic exercise ability.

 

If Anatabloc really does reduce inflammation, then it’s possible that it might help delayed muscle soreness —the pain we feel after working out too much. There is an “Inflammation theory” of delayed muscle soreness. But, theory aside, it’s a big step to say Anatabloc reduces muscle soreness or helps exercise based on the testimonial of somebody who  has a financial association to the company that makes Anatabloc.  Again, maybe it does or maybe it doesn’t. Just show me the published research.

As I understand it John Isner is the second athlete to endorse Anatabloc. The first I became aware of was pro golfer Fred Couples.

Anatabloc side effects

I’m not sure if Anatabloc has any bad side effects at this time. The mouse research I saw showed no side effects. One pdf document I discovered online titled “General information Anatabine Citrate” (Google it and it should pop up) noted that when rabbits where given anatabine, there was a reduced birth weight in baby rabbits. This however this did not seem to impact the health of the baby rabbits.

Because anatabine “looks” like nicotine, its possible that Anatabloc may alter the moods or emotional state of some people.  Feelings of depression have been reported by at least one person who commented on this review (see the comments for more information).

 

Does Anatabloc help weight loss?

Some websites discuss the issue of anatabloc helping people lose weight or if it might help reduce weight gain that sometimes happens when people quit smoking. Currently, I see no published peer reviewed proof that Anatabloc helps people lose weight or reduces weight gain following smoking cessation.

 

I mentioned above that one unpublished rabbit study noted lower birth weights in baby rabbits. Might this be the “proof” behind the online buzz that Anatabloc helps people lose weight? I don’t know but if it is, then I say save your money on Anatablc-weight loss supplements.

 

I’ve also read at different websites that there are plans for an Anatabloc face cream. I recommend saving your money on this until there is human research proving that this skin cream firms the skin.

 

Should I invest in Star Scientific?

Because Star Scientific is a publically traded stock —and because Anatabloc might have some medical applications down the road — it’s likely that people will see websites that list all sorts of amazing things about Anatabloc. Be careful because sometimes unscrupulous people say things about a company to create hype and pump the stock price up. They then dump the stock later, for a profit. This trick is sometimes called “pump and dump.” Unless you’re a pro at investing (think, Warren Buffett), I recommend you talk to a financial advisor first before risking any money.

Ordering Anatabloc

As I understand it, there is a “free trial” where people can order a sample of Anatabloc for under $5. Ordering the free sample means you will have to give them your credit card. It also enters people into an autoship program where they send Anatabloc each month. You must cancel this auto ship before the allotted time period expires or your credit card will be charged about $80 per month. Be sure to ask how long you have to cancel if you take them up on the free trial offer. Those who do not want to go through this can also get Anatabloc from GNC at full price (about $100 per bottle).

Does Anatabloc work?

This is the big question and for now, I can only say that I don’t know. I don’t know if Anatabloc will help arthritis pain, multiple sclerosis or any other condition. The research I saw looked very preliminary, too little in fact for me to justify the cost of Anatabloc, which at GNC, was about $100 a bottle. Still, I know -and understand – that people who are seeking answers will try it because $100 is a small price to pay for pain relief.

While from a cell physiology perspective, there may be something to Anatabloc (because of anatabine), the lack of human research makes me skeptical. There is a part of me who wonders if Anatabloc is just another product, rushed to market, based on little proof, but there is another part of me who’s intrigued. Still, the scientist in me needs better proof than what I see so far. So, I’m hoping that people write and let me know if Anatabloc helped them or not. Right now, I’m on the fence.

What do you think?

{ 758 comments… read them below or add one }

Jody April 30, 2013 at 5:11 pm

Can’t you just EAT eggplants, tomatoes, peppers, etc.? Eating healthy strengthens the immune system, I don’t think anyone would debate that. I can buy a fair amount of healthy food for $100!

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adamr826 April 30, 2013 at 6:06 pm

Jody You would have to consume well over $ 100 of “eggplants, tomatoes, peppers, etc to derive the same amount of anatabine in a bottle of Anatabloc.

People purchase Anatabloc for $ 80 bottle from GNC for 300 or $.27 pill. So based upon weight of 120 pounds this would be 6 or $ 1.62 day or over 220 would be 12 or $3.24 a day. Both below the cost of a single Starbucks coffee a day.

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Joe April 30, 2013 at 6:17 pm

Adamr826, but if they ate the food, they would get a broader spectrum of nutrients. There is more to those foods than anatabine.

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Tom S April 30, 2013 at 8:20 pm

Joe,
No question there’s a broader spectrum of nutrients and calories in those foods. However one would have to eat a mountain of them to get the same amount of anatabine citrate in just one lozenge of Anatabloc. I think you knew that and yet, well, I don’t know why you wouldn’t spell that out.

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Joe May 1, 2013 at 8:30 am

Tom S, I was not saying that foods would provide the same levels of anatabine. I understand anatabloc is more concentrated. I mentioned it because the big picture is not just about anatabine and the foods Im thinking of dont have a lot of calories – fruits and veggies.

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Bill May 4, 2013 at 8:11 am

Joe, I appreciate an understand your opinion. Unfortunately, the majority of Americans do not follow this type of diet. That said, even if they did, I seriously doubt they would get the same benefits that Anatabloc provides to people suffering all sorts of inflammation related illnesses. I am a perfect example . I am fit and eat plenty of fruits and vegetables. But, I still suffer from allergies and arthritis. Both of which have been eliminated by Anatabloc.

ann April 30, 2013 at 7:03 pm

Oh, it’s more than just all that…it’s the alkaloids from these foods which are nightshades which many people avoid, me for one, and the tobacco element in this “science” of this supp. Somehow it works for many who take it….I’m not into eating lbs of nightshade foods…read the science of Anatabine.

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Gail L May 1, 2013 at 2:37 pm

All the nightshade plants have atropine, concentrates are best left alone. Anatabloc is not atropine. Totally different.

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Jody May 1, 2013 at 6:55 pm

It is true that some people are sensitive to nightshade plants and should avoid them. But the point of this blog is that the science is lacking at this time. I am happy for the folks that have found relief from their chronic pain while on this supplement, but people need to be clear that the evidence of efficacy in humans is circumstantial or a leap of faith at best.

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ann May 2, 2013 at 11:44 am

What else is there but human circumstances, I took the Leap of Faith and I’m taking less advil, sleeping a good long stretch, waking up in NO PAIN, and as I approach my 4th month, finding I’m taking even less of the lessened advil I was taking for yrs prior….Humans are the best evidence and our circumstancs of what we are experiencing is what it is…I’ve tried mega other anti inflammatories, a pharma one put me in the ER in the 80′s, so I avoid pharma drugs at all costs to my body…and mind…

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Jay May 1, 2013 at 4:10 am

Joe, Yes whole foods are better but many people eat fast food and don’t get the vitamins they need. Anatabloc is a supplement that works for some people in areas such as anti inflammation but doesn’t work for everyone. So far it’s helping me even though at a high expense. I wish I could find something cheaper with the same results but so far no luck. By the way, I have lost some weight, quite easily, so I can reduce “A” to 10 per day vs 12.

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Free100KSecret May 1, 2013 at 10:39 am

Interesting,

Having been on Anatabloc for five months, only recently upping the dosage as recommended, I have seen several benefits to date.

I have had issues with swollen ankles after standing for hours at events I attend, or walking for more than a few miles, and it was consistent. Well, not anymore, and I have pushed myself just to verify that the swelling is no longer an issue. So this was my first benefit which I was able to verify.

I also had bad knee from old motorcycle accident which would act up whenever I pushed myself, and I always knew when it was about to storm well ahead of weather reports for my knee would start hurting. No more pain, even after a run which I had not been able to do in decades without paying for it with pain for days. So this was my second benefit realized.

Now here is where it gets interesting, I have had ongoing issue with inflammed gums which would act up every other month even after having a root canal which was suspected to be causing a decade of pain, to no avail, it continued for years after root canal. Granted, I do have receding gums which were also treated, but nothing helped with the swollen gums which would act up on regular basis every other month.

I have not had this annoying pain for over four months now, in fact, my gums have never looked better, and I swear my receding gums are getting better, but I didn’t connect the dots to Anatabloc until hearing it benefits gum disease recently, so it is not a case of placebo effect in my case, and as a skeptic on supplements to start, I am becoming a true believer based on personal results.

Now here is the next benefit, which again I did not know would impact weightloss when I started. I was only focused on my swollen ankle and knee pain issues. Having just read some posts on those who are losing weight, it got my attention for I have mysteriously dropped 18 lbs. which was near impossible for me in the past having tried every method and product known to lose weight. So is it Antabloc, I don’t know, but I have not been doing anything more than I was over the past four months, in fact, even less do to work load, so I have not been exercising as much as I would have been doing if not so busy at computer. So is this an aid to weight loss, who knows, but having tried to drop 20 lbs. for decades, this was a shock.

Good health to all, Mike

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Tom S May 1, 2013 at 1:13 pm

Mike,
My dentist and hygienist were so impressed with the improvement in my gums that everyone in that office takes Anatabloc now. My dentist is sort of a ‘large’ guy and raves now over how much better his knees feel.

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Randy May 2, 2013 at 2:33 pm

Wow, i too used to have Gum flare ups constantly, like every week. Since i have been on Anatabloc ( only 1 pill a day) since October 2012 my gums have never flared up since. And my last checkup my dentist said my gums looked remarkably healthy. My prior check-up i was told i needed Gum graft surgery. No kidding Joe, this cant be a placebo effect.

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Anonymous May 1, 2013 at 10:02 am

I searched on PubMed/Medline and the only new study I found was one about a new ay of measuring anatabine. Nothing involving human clinical trials.

Anal Chem. 2013 Mar 19;85(6):3380-4. doi: 10.1021/ac400077e. Epub 2013 Feb 27.
Application of GC-MS/MS for the analysis of tobacco alkaloids in cigarette filler and various tobacco species.
Lisko JG, Stanfill SB, Duncan BW, Watson CH.

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Dorothy May 3, 2013 at 8:50 am

After years of using prescription drugs (with minimal relief) for arthritis pain, which resulted in bleeding ulcers, I tried Anatabloc. 3 weeks of dissolving 2 tablets 3 times a day has convinced me. I had debilitating thumb joint pain for years with minimal results from the prescription drugs. Now I am almost pain free with an incredible range of motion. My hips and knees also are pain free.

There was a human study in Florida which ended in January. The results are not posted yet. Based on the side effects of the prescriptions I have taken (stroke, heart attack stomach bleeds etc.) I’m willing to continue to take it until I find results with negative sided effects. I paid 79.99 at GNC and over 160.00 for the useless prescriptions. I’m keeping an eye out for the human study results.

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joy May 3, 2013 at 2:46 pm

Dorothy, amen…I ended up in the ER in the early 80′s from a pharma drug for inflammation, so I know that one…so for me, going into my 4th month, anatabloc is where it’s at for this body and MIND…..

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Gram May 3, 2013 at 4:47 pm

I have been using Anatabloc for 2 weeks now. This winter my joints caused me extreme sharp pain …. I was taking anywhere from 3 to 5 liquid Aleve pills a day just so I could be free of the heavy, sharp pain. Within 36 hours of taking Anatabloc the sharp pain in knees GONE; and as of yesterday the sharp pain upon lifing my legs up just to get dressed is now GONE ALSO. I will say that my leg muscles still are tight and need ‘therapy’, but the PAIN IS GONE.
I learned of the product from Fred Couples’ ad; went to GNC store and was told it is a very popular. Went on Anatabloc’s web site and decided to give it a try; they guaranteed I could stop the automatic shipment of the product ‘at any time’………….
I would recommend this product to ANYONE who suffers such joint pain.
I will also admit I have not been to see my physician for any of this pain, thinking arthritic pain is just that and except for drugs the physician couldn’t help anyway.

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Jay May 5, 2013 at 2:20 pm

Joe, As I’ve written on your Board before, I’m not a stockholder or have any interest in “A” other than it seems to help me lessen pain. I’m only in my 4th month but still see results.Currently losing weight so should be able to drop to 10 per day vs current 12 per day which would save me some money. As a 70 year old, money saved is a bonus. The scandal with the Virginia Governor is probably not going to help the Company and could cause severe consequences.

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Joe May 5, 2013 at 4:13 pm

Jay, thanks, yes I’ve also been reading about the VA governor and anatabloc. Time will tell.

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joy May 5, 2013 at 6:27 pm

It’s a great mystery, TO ME, about Star Scientific and I only HOPE the product will be around and it would be nice to see a reduction in price….Joe, for people to know if it “works” for their chronic pain issues and for me, my stuff was horrible, is they have to give it a try.

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Sherry May 6, 2013 at 8:37 am

I heard of Anatabloc from my husband who was told about it in the golf arena. I have bursitis in my left hip. I decided to try Anatabloc despite the price tag since the pain in my hip was so bad that I could not sleep at night.

My doctor had said that the only thing I could do was to “manage the pain” and suggested constant prescription strengths of ibuprofen. After taking this for 3 days…I was almost pain free. I fall asleep at night and I can lay on that hip for about a half an hour at a time now and before could not last 15 seconds on it.

I am in NO WAY associated with any the Anatabloc company and I despise tobacco companies and the fact that it was produced by one….did disappoint me….and I did do my research first. I decided to try it……it is working. It is the first thing I have found that works for this type of pain. For what it’s worth….a bottle lasts me a little over a month….. the lack of pain is well worth it.

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Joe May 6, 2013 at 12:29 pm

Sherry, for what its worth I hear Star Scientific is getting out of the tobacco business. I’d also mention that drugs or anatabloc, both are only managing your pain, as your doctor mentioned. I’m not aware of any evidence – so far – that proves anatabloc repairs the damage. We will all just have to wait and see what research they publish on this.

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Sherry May 6, 2013 at 1:29 pm

Thanks Joe-
I agree……I am not sure why the pain is better, but I’ll take it for now!

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Robert C. Barker May 6, 2013 at 4:36 pm

The contents of their internet ad which arrived today, along with your online observations regarding vague location of their business,the extraordinary claims made in the absence of controlled human studies, and the fact that it is apparently marketed as a food supplement (probably to avoid the need to demonstrate scientific evidence of efficacy) all suggest that these guys are a bunch of scammers who may or may not have valuable product.

The only thing they have not done to discredit themselves further is to resort to ‘multilevel’ marketing.

Good work!
Robert Barker

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joy May 7, 2013 at 4:05 pm

Joe, for me I was at my lowest point ever in my life since the hip replacement in late 2010…I have had OA and Fibro for mega yrs. but this replacement pushed me into a totally new pain world…talk about inflammation….

I hear you about trying everything you review…..take care. There are MANY many in mega pain out there and many take so many drugs with horrible side effects….

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Joe May 7, 2013 at 5:08 pm

Joy, I hear ya. Glad its helping you. I’m hoping that the research bears out what you and others are saying.

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Maurice May 9, 2013 at 8:30 am

Hi Joe, I posted in February about how Anatabloc helped control persist chronic swelling of my upper lips. I was diagnosed with CHEILITIS GRANULOMATOSA an auto immune disorder that was quit terrifying to say the least. I went to see my specialist yesterday and he was amazed at how my lip had healed and responded to the Anatabloc. My doctor had never heard of Anatabloc before but after reading the ingredients on the bottle he suggested that I continue taking the supplement.

In a few months from now I will discontinue taking the Anatabloc and see what happens. This product has been a game changer in my life. I feel great, lots of energy, my brain seems to focus better, and most important I can look at myself in the mirror. Thanks Joe.

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Joe May 9, 2013 at 8:37 am

Maurice, thats great news glad its helping you! Id say if its helping you then stick with it. While Im all about the science, I want you to have a good quality of life and if this is giving you that, without side effects, then I’d say keep doing whats working :)

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joy May 9, 2013 at 12:45 pm

Maurice, why totally discontinue…you could have a setback, you’ve come so far is sounds like….maybe just drop the dose and see what happens…I don’t know how much you are taking now, but lower dose maybe…that’s how I’d handle it…with such success I’d hate to have a setback…just my thoughts…it works in SO MANY ways overall as you are saying….

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Maurice May 9, 2013 at 2:21 pm

I guess I should clarify something. I have no intention of quitting Anatabloc in the near term, but, perhaps in a few months or a year from now I would slowly reduce the dosage and see how I respond. I have to admit I am a bit curious! We might have some research results back by then and more information about the product. I will also have my annual physical this summer and see how it has affected my cholesterol levels and my TSH. My TSH rose significantly on my last physical and I am betting that its lower now. We will see.

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Joe May 9, 2013 at 3:53 pm

Maurice, Im very curious to learn what happens to your TSH levels. please let me know :)

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Allan May 9, 2013 at 5:17 pm

Maurice ——-

Really happy for you re: the results that you have experienced with Anatabloc. One can only imagine how it feels for you to be able to like yourself again looking into a mirror. That is really fantastic. Thanks again for sharing your experience.

I agree with Joy re: not getting to curious on the “what ifs” if you reduced the Anatabloc or discontinued it completely for a while. The benefits you have achieved are to important to you to second guess the continued benefits for you and to risk a setback doesn’t make sense to me. I expect the documented science will surface in the future that will agree with your findings, IMHO.

You could be an excellent ambassador for and to other folks with

CHEILITIS GRANULOMATOSA that have never heard of Anatabloc and its potential benefits for their disease. For them to read or hear about your testimony could be a life changing experience for them.

I wish you well and continued good health.

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Allan May 9, 2013 at 5:29 pm

Sorry — follow up ———–

I met to included the comments below:

Along with Joe re: your TSH, I would really be interested to hear what your upcoming readings are for “Highly Sensitive C-reactive Protein” C-RP test. Optimum Levels are :

Below 1.3 mg/L of blood is safe

Below .5 mg/L of blood is ideal.

CRP is a measurement of “Chronic Inflammation” in your system.

After taking Anatabine via CigRx and then Anatabloc when it came out, my last CRP measurement was .1 mg/L.

GLTA

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Jay May 11, 2013 at 2:49 am

Joe, To your knowledge is C-RP a regular test? When my back pain was so severe, they did all kinds of blood tests on me and established that I had high inflammation but not one of the tests showed my C-RP.Even though I’m into four months of using “A” I can only say that it is helping with the pain but not getting rid of it. I must be getting some benefit or I would not spend $80 per month on my limited budget. So far so good and depending on your answer and others, I may ask my doctor for a C-RP test. Thanks again for a great website with all this input. I really enjoy listening to Joy.

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Joe May 12, 2013 at 12:11 pm

Jay, you usally have to ask to have a CRP test done. I don’t think doctors regularly test for it.

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Jody May 12, 2013 at 3:33 pm

A C-RP test is a non-specific test that shows if inflammation is occurring somewhere in the body do to some mechanism. I feel it is important to understand that inflammation in this case means activation of the immune system, not necessarily swelling and pain. Although you may be experiencing both as part of your immune system’s response. If your physician already knows that you have inflammation and especially if the cause is known, there is no benefit to a C-RP test. As more specific tests for specific conditions have been developed over time, the C-RP falls into disuse since it is not specific.

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Joe May 12, 2013 at 4:01 pm

Jody, true CPR is a non-specific test. Since Anatabloc is touted to reduce inflammation, I feel a study of its effects on CRP is warranted.

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Robert Brink May 11, 2013 at 3:19 pm

On a plane trip from Florida to Iowa and back last June, my rear end was so sore I had to get up and walk. I had x-rays, and arthritis was the cause. I began taking Anatabloc. On a trip to Wisconsin in February, I had no soreness. I used to have difficulty lying on either side in bed because of pain in my shoulders. It’s gone. I was walking briskly and developed occasional pain in my upper thighs. That doesn’t occur anymore. My right hand was stiff. No more. I’ve been running sprints and doing squats and abdominal exercises, etc., which have been causing back and neck pain.

In recent days I increased the dosage to the maximum six tabs a day (three to four previously), and the pain and soreness seem to be lessening, though I need more time to assess. I am, after all, 75 years old, so it might take a little longer to kick in.

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Allan May 12, 2013 at 4:01 pm

Robert, thanks for sharing.

I’ve experienced the same body / system improvements that you speak of and to the point, I find myself having to throttle myself down so that I don’t get carried away from feeling so darn good.

I take 2 Anatabloc 5 times a day. I weigh 200 lbs and am 70 yrs. young and on Anatabloc, feel like I’m getting younger.

Have a great day and GLTA.

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Anonymous May 12, 2013 at 1:15 pm

Jay, one has to ask for CRP….I will get one with my labs in Aug when I go in for annuals…thanks for your mention….

I too am on limited funds and “know” I’m getting relief with abloc, I’d like more but my body is wracked with lots of stuff, from advanced OA and Fibro and the hip replacement complication inflammation…

I sleep really good NOW but still wake up stiff and the beat begins each day…but I do sleep…

Whether things will improve with time, I don’t know…I’m headed into my 5th month and I take 8 per day….but NOT out of all pain believe me…I’ll be 3/4 century this summer….so as my cousin said the other day and she’s 88, the longer we live the more we have to deal with and our aging bodies…she went thru 2 hip replacements and I’ve told her about Abloc…even with new hips, one is NOT out of pain…I’m in more pain in many ways with the new hip…

Take care…

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Jay May 12, 2013 at 6:26 pm

Joe, thank you and everyone for the input on CRP. Since it was known that my back muscles were highly inflammed, I guess a CRP test wasn’t necessary. Interested in others test results as that should shed some light on effectiveness of Anatabloc.

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Joe May 12, 2013 at 7:56 pm

Jay, CRP will shed light on Anatabloc. If its anti-inflammation, CRP should go down.

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Leo hornsby May 17, 2013 at 12:27 pm

I am on anatabloc for two weeks ,no results yet at all.i will continue the trial offer. I was contacted by a company rep.who wanted to be my “coach”‘,probably to buy more of the product. I suspect a hustle. Ralphie

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Joe May 17, 2013 at 12:50 pm

Ive never heard of anatabloc coaches. do they work for star scientific?

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joy May 17, 2013 at 1:25 pm

There are no coaches, don’t buy into that crap….I have several 800# for HELP with your order and product and if you want them let me know and I will post….

Also an 800# for MD and pharmacist to help…

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Joe May 17, 2013 at 2:50 pm

But who are these “anatabloc coaches?” are they associated with different companies that sell anatabloc? What do they do to coach people – or is it all just about “coaching” them to buy more anatabloc?

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joy May 17, 2013 at 3:21 pm

Joe, I never heard the term “coach”….but my kinda belief is that they are connected to the Trial Offer call center….and call people who bought the trial and push them into the auto ship stuff…..and often ship the product without the customer’s approval…it’s all been kinda messy for many and many have threw in the towel to buy the product….

I buy from the Curtis C/S and also from LuckyVitamin as I buy for my daughter too and use both sources….

With Curtis I can manage my auto shipments…..this works for me NOW….

Allan May 17, 2013 at 2:44 pm

I’ve been following Star closely for over two years along with many other folks and the subject of Star having coaches on its payroll or under contract has never come up in any discussions.

Also, as far as I know, Star isn’t in the hustle business either. If one sees no benefit from Anatabloc after taking the FREE trial sample, my suggestion would be to not order the product. The product will not help someone that doesn’t exhibit problems / complications from chronic inflammation.

Full disclosure:

The benefits for me, from taking Anatabloc, have been so dramatic that I have invested in the common stock of Star. I have no other connection to Star except that I truly believe that Anatabloc is a medical / health game changer that will be proven as the science unfolds.

GLTA

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joy May 17, 2013 at 1:22 pm

I’m on Anatabloc going on 5 months now, and buy from Anababloc and Lucky Vitamin, and get the 300 ct bottle for $80…. Don’t let that “coach” talk you into an order as they are trying to get rid of the 200 ct bottles for a “deal”…don’t buy into it…..don’t order your monthly order from the ones who call you….I don’t like their tactics….. Lucky sells it for the same price and you control your orders…..

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Robert Brink May 17, 2013 at 3:50 pm

Shop around the Internet for the best price for Anatabloc. I bought a bottle of 300 tabs from ebay for $75. Just make sure you’re getting the 300-tab size, not the 200-tab bottle. As I said before, the stuff works.

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Vernon May 19, 2013 at 5:01 pm

Joy, I read that you buy Anatabloc from Lucky Vitamin and also from Curtis C/S. I was able to find the Lucky Vitamin site, but can’t find the Curtis C/S site. Would you tell me how to get to it – possibly the web address. Thank-you, Vernon

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Joe May 19, 2013 at 6:18 pm

Vernon, I dont know what Curtis C/S is. I dont think we have them here?

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joy May 21, 2013 at 4:32 pm

Update: Riding my Recumbent Bike Daily….mostly now 15 minutes and will work up to 30 slowly. Prior to hip replacement in Oct 2010, I was a gym workout queen and then used my recumbent at home…

Hip surgery threw me into a spinal stenosis mess and I could NOT sit for a very long period of time, a couple minutes at most…it was absolutely HORRIBLE….for a good year or more…

In last qtr 2012 I went thru 16 sessions of acupuncture on spine and lower back etc…and those helped….

But as of January this year, everything has improved so much that I can SIT and even riding the recumbent now….

So I KNOW Anatabloc is the best I’ve ever tried re: anti inflammatories…granted the last 3 yrs have been my worst in my soon 75 yrs….

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Joe May 21, 2013 at 7:49 pm

Congrats Joy :)

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Joe May 4, 2013 at 6:07 pm

Bill, thanks for writing. Ive heard a few others mention about anatabloc and allergies. this would be a pretty easy study to test. Ill look forward to reading it if it is ever done. glad its helping you.

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joy May 4, 2013 at 9:54 pm

Joe, if you never try anatabloc, how will you ever know For You…sounds like you are pain free. I am not on anatabloc for allergies, as my many yrs on grape seed ex pretty cured that issue for me…I have no asthma but I’m sure it would help with those asthma as that is inflammatory….

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Joe May 5, 2013 at 10:11 am

HI Joy, Honestly If I tried everything I reviewed, I’d go bankrupt buying it all! I don’t have a lot of the pain issues that many others seem to be experiencing so if I tried it and I felt no relief from Anatabloc, then people might not believe me. Or if I said “it was great” others might not believe me either. What I experience would only be a testimonial. The internet is full of testimonials and while they can offer some information, I prefer to look only at the science.

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