Have you heard the radio ads for Amberen? Amberen, is a supplement that’s supposed to be a natural remedy for menopause. Most of the ads I’ve heard included a testimonial from a registered nurse. That got me curious as I usually don’t hear nurses touting supplements. Another thing that made me want to write an Amberen review was that I discovered that most of the info on Amberen online seemed to be written for the sole purpose of selling Amberen to women. Some websites even say Amberen is the fountain of youth! I know that’s not true, but can Amberen provide menopause relief? I wanted to write a review on Amberen, based on the clinical research I could find, and along the way, help women answer some questions that they may be wondering about.
Amberen research
The Amberen website says that “Amberen has been clinically tested and extensively studied for over 30 years“. There are studies listed on the Amberen website. Let’s look at each study briefly and see what we can find out about them.
2008 Amberen study. A Succinate-Based Composition Reverses Menopausal Symptoms Without Sex Hormone Therapy. This is a lab rat study. Amberen was given to older laboratory mice for 4 weeks. Amberen treatment was noted to improve several menopausal symptoms in the mice. The study was supported by Lunada Biomedical, makers of Amberen and published in Advanced in Gerontology, 21,2 298-305 (2008).
2007 Amberen study. A Succinate-Based Composition ”Rejuvenates” Aging Mice and Alleviates Menopausal Symptoms in Women Without Sex Hormone Replacement Therapy. This study was a little hard to find. The citation on the Amberen website lists “Medline” as the source of the study but it is actually the “Russian” version of medline – Medline.Ru where the study is found. This study appears to be the very same study as the 2008 study mentioned above.
I think the studies are the same because the authors for this 2007 study are the same as the 2008 study. It just seems to be published in a different journal. This 2007 study was published in Gerontology Endocrinology, vol. 8, Art. 46, pp. 497-517.
2005 Amberen study. Succinate-Based Preparation Alleviates Manifestations of the Climacteric Syndrome in Women.
Here is the first page of the 2005 Amberen study. I was unable to find a full text version of the study online. Basically, 70 women were given either an Amberen like preparation or placebo for 3 weeks. Those receiving Amberen appeared to improve more than those who got the placebo. Study was published in the Bulletin of Experimental Biology and Medicine (September 2005), 140 (3), pg. 312-314.
Several of the authors of this study were the same as those in the 2007 and 2008 studies.
The 5 year study. The Amberen website also lists a “5 year study”. But no details of this study are given. As such it is hard to say how good it is or how the study was performed. This may not be a published peer reviewed study since I cannot find any citation for where the study was published.
The 4 week animal study. The Amberen website lists a 4 week study of older laboratory mice. No details are given about this study, but it sounds similar to the 2007 and 2008 Amberen mice studies mentioned above. I could not tell for sure since no details about this study were listed. This may not be a published peer reviewed study.
The 6 week animal study. Again, the Amberen website gives no details about this study other than that Amberen was given to older female mice for 6 weeks and it helped them.
The studies of Amberen’s ingredients are also listed on the Amberen website. ALL of these studies appear to be investigating one specific ingredient in Amberen called , succinic acid (also called succinate) - and not Amberen itself.
The studies of the Amberen ingredients (specifically succinate acid) date back to 1972 while the studies on Amberen itself dont seem to begin until 2005. This is how they are able to say that” Amberen has been clinically tested and extensively studied for over 30 years.” It’s over 30 years if you include in the studies on the ingredients (specifically succinic acid).
Succinic acid is compound formed during the Krebs cycle. This is the aerobic energy system that we all use when we break down fats and carbs (sugars) aerobically. That’s not really important but I thought I’d mention it in case anyone wondered.
Amberen Trivia: Amberen gets its name from succinic acid. An older name for succinic acid is “Amber Acid”.
Amberen ingredients
According to the Amberen website (AmberenOnline.com) I find that Amberen is composed of the following active ingredients:
- Ammonium succinate
- Calcium disuccinate
- Monosodium Glutamate (MSG)
- Glycine
- Magnesium disuccinate
- Zinc disuccinate hydrate
- Tocopherol acetate
Since this is a proprietary blend, the label only says that each of these ingredients adds up to 400 mg (in 2 capsules). We are not told how much of each ingredient is in Amberen.
Let’s now look at each ingredient separately.
Ammonium succinate
This is likely the succinate that has received most of the research since the 1970s. When I Googled ammonium succinate, practically everything I saw had to do with Amberen.
The “ingredient studies” on the Amberen website are ALL on succinate. Therefore, I believe succinate is the main active ingredient in Amberen.
When I the searched the national library of medicine for “ ammonium succinate and menapause” I discovered the 2008 study summarized above.
This study does indicate that it was supported and initiated by the makers of Amberen, Lunada Biomedical. That’s not really a bad thing. I appreciate it when a company supports research on their supplements -most companies do not do this.
Calcium disuccinate
This is just another name for the mineral, calcium. The addition of calcium to Amberen does make some sense given that low calcium levels seem to increase PMS symptoms. But studies on this issue tend to use more calcium than is found in Amberen (about 1ooo mg/day). Less calcium may also work but I could not find any research on this.
Monosodium glutamate
This is MSG, a popular food additive and is something to think about if you are sensitive to MSG. MSG can cause headaches in some people. If you read the comments section below, you will see that some people have reported headaches after taking Amberen. Other side effects of MSG can include, heart palpitations, sweating, facial numbness and chest pain.
Monosodium glutamate is related to the non essential amino acid, glutamine. Bodybuilders often like glutamine supplements because they think it will help them recover faster following hard core exercise sessions. For more on glutamine, read my review of glutamine supplements. Exercise not withstanding, the question is, would glutamine (or MSG) help women recover faster from PMS or menopausal symptoms? I’m not sure because I can’t find any research one way or another.
Glycine
Glycine is an amino acid (non essential amino acid, meaning we make this in our body). There is some evidence that glycine may help memory in both young and middle age adults. Since some women report memory problems with menopause, this may be why glycine was added to Amberen. People with schizophrenia should avoid glycine. Glycine may make schizophrenia worse when combined with schizophrenia medications.
Magnesium disuccinate
This is another name for the mineral, magnesium. There are a few studies that magnesium might help with PMS symptoms like fluid weight gain and mood changes. Studies are far from complete and tend to use more magnesium than is in Amberen, but the research does exist.
Zinc disuccinate hydrate
This is the mineral, zinc. Zinc might help muscle cramping. I could not find any specific research on zinc helping PMS or menopausal symptoms. In those who eat well, being deficient in zinc is rare in the USA. Some may have heard that zinc is needed in women who take birth control pills. But, according to one study, there is no good proof that that oral contraceptives cause zinc deficiency. Keep in mind that zinc supplements might reduce HDL levels (“good cholesterol”). Amberen likely has very little zinc but the RDA for zinc is 8 mg/day in women. As such, its pretty easy to get more than the recommended daily allowance.
Tocopherol acetate
Most know by its usual name – vitamin E. There is not much evidence one way or another when it comes to vitamin E and menopause symptoms. A t least one study noted that vitamin E did not help hot flashes. I feel the jury is out on this issue until better studies can be done.
Because vitamin E is an antioxidant, its sometimes added to a supplement to help the product from spoiling. I’m obviously guessing, but this may be why Amberen has vitamin E.
Can Amberen reduce belly fat?
Amberen radio commercials state that Amberen targets “stubborn belly fat.” From the research that I have seen there appears to be no proof of this statement. If Amberen really did promote fat loss from the belly, it would mean Amberen was capable of spot reduction. There is no credible proof for spot reduction. I don’t know why the makers of Amberen are trying to promote it as a weight loss supplement. Amberen is a menopause supplement, not a weight loss supplement. None of the research I have seen shows that Amberen helps weight loss in the belly – or anywhere else.
Amberen side effects
So far no studies have reported bad side effects from taking Amberen. If you have had Amberen side effects please comment so other women can benefit from you.
Amberen & Carol Nicholson
Carol Nicholson (Carol Nicholson-Kriegel), a registered nurse, is often heard in the Amberen radio commercials. She is also featured in a video clip on the Amberen website. Carol is identified on the Amberen website as “our menopause expert”. In the video, Carol indicates that in addition to being a registered nurse, she also owns an advertising agency and indicates that she “is in the natural products industry“. Carol also has a blog on the Amberen site.
I noticed as I watched the video clip of Carol, that her voice doesn’t sound like the voice I’ve heard many times on the Amberen radio commercials. Just something that occurred to me.
Does Amberen work?
Based on what I could find, it seems that there are currently 3 published peer reviewed studies on Amberen itself. The first study was done in 2005. All of the studies I found were conducted by basically the same group of people. All studies appear to have been performed in Russia. If Amberen works, it seems to me that the ingredient called succinic acid is the active ingredient.
I have no proof either way that the other Amberen ingredients offer any advantage over just taking succinic acid. Succinic acid supplements are available and cost less than Amberen. If Amberen really works it would be interesting to see how it compares to women who only take succinic acid.
It’s hard to tell whether Amberen will help all women with menopause or not. In theory there may be something to Amberen but how much it help might vary. While I have some reservations about the Amberen research, the studies (while fewer in number) do exist and that does set Amberen apart from many of its counterparts.
What do you think?
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I just took my first dose of RU21. Then I read the last couple of posts! That is where I got mine as well. Should I be worried? My flashes are so severe, I’m not getting much sleep. I’m waking up 6+ times a night and having to go outside in the cold or get an ice pack and them I’m wet and freezing!! GRRrr.
Of course then it takes time to get back to sleep so 4-6 hrs is usual. I’m pretty tired and cranky, but meningitis would be a lot worse. I will try to post back and let you know how RU21 is working for me.
Michelle, if it makes you feel any better, its only been one compounding pharmacy that has been linked to meningitis. Im sure they dont make RU21 – and they have been shut down. Im not aware of any supplement ever causing meningitis.
Joe, thanks for all the info.
A question: do you know if it is ok to take Amberen or RU21 along with atenelol? I take 25 mg daily for PSVT, due to a congenital heart defect (my heart will beat irregularly on occasion without it). My PSVT has never been a huge issue, and I actually tend to have low blood pressure. Thanks!
Ann, good question and Im not sure. I am not aware of any side effects with Amberen and I have not yet had a chance to investigate RU21
Thank you, Joe. That does make me feel better.
I am going to try 1 tablet every 12 hrs. I’ll let you know.
Joe,
Any safety issues around succinic acid? I found one product on Amazon, but it doesn’t show the label
http://www.amazon.com/DMSA-dimercapto-succinic-capsules-Brand/dp/B002D9IUV2/ref=cm_cr_pr_product_top
It’s a bit pricey I might add. I went right to the manufacturer’s website, and they have more pricing options, as well as 25 and 100 mg. strengths.
Regarding black cohosh, in Remifemin, it has been studied for menopausal symptoms, but I found something something on the Mayo Clinic website about dangerous blood pressure and circulatory changes after reading someone’s “comment” on Amazon. I have taken black cohosh before without any adverse effects, but that was several years ago, and I have borderline to high blood pressure.
http://www.mayoclinic.com/health/black-cohosh/NS_patient-blackcohosh/DSECTION=safety
Judy, Ive never seen any side effects with succinic acid. On some other websites they talk about how it might cause diarrhea, constipation, stomach upset, nausea and darkened or green stools. I cant confirm or deny any of this and they dont show any proof of it so take it for what its worth.
Black cohosh has been controversial in come circles and I think if you take it, its best to keep in contact with your gynocologist who is likely up on all the latest research.
Thanks Joe. Vitamin Research Products, the company that makes the DMSA (dimercaptosuccinic acid) form recommends that it be taken under the supervision of a physician. http://www.vrp.com/digestive-health/dmsa
Another brand of succinic acid has been discontinued on the http://www.iherb.com website. Makes me wonder why?
Judy, interesting. they say their form of succinic acid can cause the depletion of minerals. in theory this might alter heart rate and blood pressure among other things. That may be why they say talk to your doctor. they also say its been used safely since the 1950s. if that is true then succinic acid is classified as “GRAS” which means generally recognized as safe (its a term used for things that have been in the food supply for at least 50 yrs). Im not sure if Amberen has this same type of succinic acid or not. I dont remember seeing any warnings like this on the Amberen website. Best I can say is do what they recommend and talk to your doctor before you use it.
I am an Amberen success story. My menopause symptoms (hot flashes, heart palps, trouble sleeping etc.) started when I was 57. I tried Estrodial and Progesterone (bio-identical) and had trouble with spotting and little relief from other symptoms. Long/short, I went on Amberen and forgot I was in menopause.
I am now post-menopause and have no symptoms without Amberen. In fact, I found it was time to go off it when taking it caused symptoms. The nice customer support people told me that perhaps I didn’t need it anymore. I don’t. That’s also the nice thing about Amberen–it was never intended to be something you have to take forever.
Because I am very inquisitive, I sent an email to one of the Russian scientists. He was very helpful and interesting. I may have burned that bridge, though, from too much inquiry, because he did refer me to one of their other experts for help. I have a high level of respect for this company and the people who work there.
A couple years ago, I tried Amberen. After several weeks, I experienced no change or relief in symptoms (hot flashes) and so doubled the dosage as instructed. Several weeks later, I developed cracked, peeling lips and cracks in the corners of my mouth that were painful and would not heal. The only thing I could attribute to it was using Amberen as that was the only change in anything I was taking and I had never had this before. I stopped Amberen.
The painful cracks continued and I ended up having to go to the doctor to get a steroid cream, which eventually cleared it up. A year later I went to a HRT specialist who put me on bio-identical hormones (all menopause symptoms have been relieved with this) who said Amberen is basically junk. Additionally, Amberen did NOTHING for weight loss. I wholeheartedly do NOT recommend Amberen for anyone.
It is possible, some needed nutrients were lowered, in your system, by taking Amberen.
Or it could be a coincidence.
One can take certain herbs, noted for wonderful results, and get similar symptoms–like using cayenne pepper for pain. It is, in Chinese medicine, a ‘heating’ herb, which increases Yang energy [hot, dry]. If one uses it too long, [varies per person] they can get the kind of cracks around the corners of the mouth as you mention, and cracks at fingertips/corners of nails, etc.
The conditions usually mend in days, when the cayenne is stopped, or, if it is well-balanced with other herbs taken in a synergistic mix.
Not knowing if/how/which ingredient[s] in Amberen might have caused this, it is hard to say why or what to do about it.
Normally, i would suggest using a nutritive good oil, such as virgin coconut oil [nutritive, non-staining, easily available], on the cracked skin, to help it heal.
Some have opened high-dose Vit. D3 caplets and put that oil onto the sore spots.
The question is, what nutrients were lowered in your system. Without knowing that, it is difficult to say what might help you get better.
But there are some general things just about anyone can use:
Good fatty acids, such as therapeutic amounts of DHA fish oils, virgin coconut oil, virgin palm oil, Mt. Capra Mineral Whey, Vit. D3, etc.
A good lot of the causes for menopausal symptoms [and other ills/ailments], can be related to imbalances in nutritional elements, either by failing to consume them, or being unable to absorb or use them; consuming unhealthy foods/drinks; unresolved stress; exposure to unhealthy environs; sleep deprivation; etc.
When we learn the root causes for any problem, finding a solution is far more effective than any ‘band aid measure’! Unfortunately, our society is long on band-aids, and short on finding root causes.
Band-aid measures are far more lucrative.
I have been taking Amberen for 6 weeks now, doubling the dose as directed when I had no change in my symptoms as well. I think I am going to stop taking it. I have an odd salty taste in my mouth, pretty much constantly, but no sinus issues or post nasal drip that I can attribute it to.
I work in an air conditioned environment, but experience drenching sweats 6-8 times a day. I am still not sleeping more than 6 hours a night, and that is interrupted by the night sweats, so I feel pretty miserable.
I have called and spoken to the nurse, explaining the continued symptoms, but she seemed patronizing, and asked what I expected from the product (pretty much what they advertised!). Anyway, I am very disappointed, and feel it was a waste of $100.00. I am happy to hear it helps some, but I would not recommend it to anyone.
Heard a commercial about Amberen helping with hot flashes, night sweats and weight gain, which I had all three. Started taking it in September. Started just taking 1 dose for a few weeks which did help with the hot flashes and night sweats, but NOT the weight loss.
Doubled the dose after that, but still NO weight loss.
I never had a weight problem until I started going through menopause and I thought Amberen would help since the commercial says helps with getting rid of that belly fat women get during menopause.
Another thing when the commercial says you get a 30 day free trial – that is false. You don’t get 30 days free unless you buy the 90 day packet.
I’ve been using Amberen for about 45 days. It relieves my night sweats almost completely, I don’t yet have hot flashes. In that time I’ve forgotten to take it a few times and all my symptoms coming roaring back at an alarming rate. Which makes me really nervous about taking a break. I have noticed weight loss, a lessening of appetite and less “yo-yo-ing” on the scale…once I lose it it seems to stay gone, so far. It seems to do what it advertises, at least for me.
I’ve been on Amberen since Oct. 29th. Had to increase to double dose in week 3 for 2 weeks as recommended. I have had an “off” feeling every since being on this product. I cannot articulate the feeling.
It’s just a feeling of something is “off” not right inside me. It did reduce hot flashes, mood swings, but I have had a sudden hypersensitivity to sound, touch. And teeth sensitivity has heightened. I was told that menopause can cause this too.
Anyhow, was wondering if anyone had experienced the hypersensitive symptoms. When a dog barks it sends a chill up my spine from the piercing sound. I also can barely open an envelope with a letter opener.
Closest description is like when someone runs their fingernails across a chalk board. Sends a chill up my spine. Now I did start acupuncture (never did this before) the same time I started Amberen for Restless Legs Syndrome. I’m giving that up because cannot afford it and not sure if it’s helping or not.
I’m ready to get an Rx (another one) for RLS and blasted anxiety. I feel like I’m on the verge of a constant PANIC attack. Best description is feeling like you’re entire body has been turned inside out with all nerve endings exposed.
Anyhow, just wondering if anyone else has just felt like you were internally “off” on edge just not right. I think I’m going to stop it after 5 weeks. $100 down the drain.
That sensitivity sounds like it might be related to minerals being depleted, or other nutrients being low.
There are various supplements that do a great job of supplementing minerals, including sea veggies [kelp], Mezotrace minerals [for those who can't tolerate the iodine levels in kelps], and Mt. Capra Mineral Whey.
Chi, you seem to have it figured out. Are you a holistic practioner? I’m asking, because if you are, I wondered if I might contact you for help. I am all about holistic/natural remedies. I’m no expert on Amberen. I have never tried it. Just heard about it on the radio and thought I’d read some reviews to see what real people had to say about it. I do know that MSG which is in Amberen is NOT GOOD for anyone. Why would they put something like that in it?
Anyway….. I have hypothyroidism as well as other “chronic” issues that “mainstream” just isn’t resolving. Now I am peri-menopausal which is making everything almost unbearable at times. PJ, above mentioned just about how I feel 90 % of the time. Hypersensitive, can’t deal with noises or crowds or really the least little thing. I too feel that I’m on the verge of a CONSTANT PANIC ATTACK. It’s awful.
It would be nice to maybe get your email address and be able to be in touch to find out if in fact you are a practioner and could help or to find out what your information source is since you really do seem to have a lot of knowledge on the natural approach to healing. If peri- menopause is this bad, I don’t even want to think about menopause.
I have heard those symptoms related to high doses of zinc before. Since there is zinc in Amberen, that might be the connection.
@ P.J. I have been on Amberen for 1 1/2 months now, and I love it. I don’t have any of the symptoms that you are describing? The only thing I have is at night my heart flutters a bit, but I had it a little bit before taking the Amberen.
I love this product and it is really working for me. Maybe give it a little time and stop all the other stuff you are doing. Maybe some other Rx you are taking is reacting with the Amberen. I would talk to your OBG about it. Good Luck.
Might try adding something simple to your intake, like sea veggies [kelps], if you tolerate iodine OK.
These come as snackable crunchy ‘leafs’, very low calorie, tasty–I got some from Costco, even.
Those provide about every mineral we need and then some, in one package a day, approximately.
They are traditional foods in many cultures, such as Irish and Japanese.
Everyone has talked about the ru21. I bought it and I’m ready to give it a try. The dose is 2 before drink and 2 after drink, but I’m not taking it for the drinking. What would be the way to go for perimenopause.
I did have blood work done 3 months ago due to fibriods and heavy bleeding. It turns out I have an over production of estrogen and I’m anemic. The holistic nurse recommended progestron and iron. Have done this and feel the same. Any advice.
Oh to add, have been in a high stress situation for 2 years (cheating spouse and divorce). Wondering about the adrenal gland. Have had the thyroid checked. All well.
It is important to do what is needed, to lower stress. Get counseling [if one is not compatible, or lacks money, it takes more looking to find just the right one].
Many have been in similar situations, and there is far more to address than what is superficially discussed here. It sounds like your holistic nurse suggested some good things, but more by way of ‘band-aids’.
Those you mentioned can help short-term, but might cause more problems long-term [like blood clots in the legs with long-term progestin use--natural progesterone is some different].
Some women have serious difficulties absorbing iron, which requires a different form, to get it into the body to use.
Nutrition is key.
Moderating stress, is imperative.
One can take boatloads of pills, but if the causes are not addressed, it is just boatloads of pills slightly helping symptoms.
Kimberly
I see my GYN the 21st. Will discuss with her then. All I know is the AMBEREN is the newest item I’ve added. I didn’t have the noise, sound and hypersensitivity from previous Rx’s until the last month. Yes, it did help with hot flashes and night sweats after I upped dose to 2 pills/day for 2 weeks. But as soon as I went back to regular dose on week 3 hot flashes and night sweats started up again. And, the hypersensitivity to certain sounds (high pitches) puts me over the top. It’s probably just me going insane
Didn’t one of the ingredients cause a problem for those with schizophrenia?
If it does this, it would make sense that those who do not manifest overt symptoms of schizo, might have just enough “under-the-radar” imbalance that it could push them into symptoms like the hypersensitivity to sensory input.
Chi, I don’t recall any link of Amberen ingredients to schizophrenia.
Try this site:
amberen.com/ingredients
go down the page to Glycine.
Other sites described the mental imbalance issues with glycine, too.
Then there’s that pesky MSG in Amberen, also…which can also cause problems, not necessarily mental imbalance, but can have emotional imbalances and hypersensitivities.
Chi, I did some digging into this and I think I know where the link to glycine and schizophrenia is coming from. There are some studies noting that glycine can help some schizophrenia drugs work better. Here is a link to one of the studies.
http://www.ncbi.nlm.nih.gov/pubmed/23286991
So glycine appears to be something researchers are looking at as a treatment for schizophrenia.
That said, I did find one study noting that glycine might make schizophrenia worse when it was combined with a medication called clozapine
http://www.ncbi.nlm.nih.gov/pubmed/9892314?dopt=Abstract This study does date back to 1999 and Im not sure if it was ever replicated. Could this be the reason why people online are saying glycine might cause schizophrenia symptoms in some people?
Since changes in mood can accompany menopause, might this be the reason glycine is in Amberen? I hope not because I would not equate menopause with schizophrenia
I do appreciate the issue of glycine being raised because until today I wasn’t aware of the schizophrenia link.
PJ,
Thanks for the laugh. I just read your above comment. I too have the same symptoms you are having. I guess “misery loves company” but I feel better knowing that someone else is experiencing this “crazy” stuff. If you’re going insane, then I’m right there with you….lol I can’t deal with loud noises (esp. high pitched….my Maltese barking is like a train going by or a needle being stuck in my ear), and the feeling like I’m on the verge of a “constant panic attack”, like you mentioned in another post. I feel the SAME EXACT WAY. It’s scary and miserable. No two days are the same anymore. Life is becoming completely unpredictable.
I have never taken Amberen. I am just here to read about it. Thus far, I’m not impressed with what I am reading. The MSG component was the first thing that turned me off because MSG is not good for anyone to take.
I think Chi is on the right track as far as our symptoms being more of a nutritional/mineral/vitamin/fatty acid, etc. deficiency. I wanted to add that sometimes those deficiencies can be caused by a “leaky gut”, which most everyone has heard of by now but “mainstream” doctors don’t ever talk about it. I supposedly have “leaky gut” syndrome, where I don’t absorb what is good for me, as well as my “gut” lets things out of my digestive system into my bloodstream that AREN’T good for me (like chemicals in processed foods, etc), instead of digesting them and eliminating them. The toxins supposedly can cause all sorts of weird side effects, which unfortunately I have.
Our “guts” are vital to our health, I do know that. The gut is where many brain chemicals are formed and the gut is a huge part of our immune system. As we get older we don’t absorb nutrients as we once did (leaky gut or not), thus most likely leading to the decline we are in.
There are ways to fix a leaky gut but it takes time and effort. It’s worth it to feel better though. I have had to go on a gluten free diet to help fix mine because gluten was causing inflammation all over my body as well as in my digestive system. I was tested for celiac disease and the test was negative. However, someone suggested that a gluten free diet might help anyway. It takes several months of being gluten free to see a difference sometimes because it takes that long for gluten to completely get out of your body but I have felt much better in general being off of gluten. Also, digestive enzymes can help with mal-absorption of food and nutrients.
There are other ways to get some of the minerals/vitamins that we need as well.
One thing that I do to get my magnesium level up (since supposedly magnesium is not easily absorbed by the stomach of ANYONE) is to do Epsom Salts foot baths twice weekly. I have noticed that my muscles aren’t as stiff in my neck and legs from doing this. It also helps with constipation and it helps you sleep better which are both so important.
I hope I didn’t get too off track with the leaky gut thing, but I wanted to mention it since I am having the same symptoms you are having. Hope it helps.
I have not tried Amberen and most likely will not do so due to the MSG and the exorbitant price.
I have used Menopause Balance Complex put out by Shaklee. The only thing is if you are on a statin drug, check first to see if there will be a drug interaction with the black cohosh.
MBC did a great job in calming down many of the menopause symptoms I was having including the hot flashes and the clothes on/clothes off game….. I took it twice a day for the first week to get things back under control and then dropped back to once a day.
I’m 54 and postmenopausal. I also have fibromyalgia and struggle with depression, for which I receive medical care, including prescription pain, sleep, and antidepressant medications. These things are so hard to share with strangers in a setting like this, so thank you for your kind understanding. I’ve recently discovered that I’ve got a Vit D deficiency as well, so started prescription strength Vit D.
I don’t know enough about natural supplements. I do know that I’m tired of being on synthetic pharmaceuticals though. I have never tried HRT because I’m concerned about the long term effects.
I was really feeling desperate when I ordered Amberen. I’ve been on Amberen for about 3 weeks. I started noticing a difference at 2 weeks. I haven’t lost any weight yet (I’m about 15 lbs over weight) but I’ve noticed that I’ve got more energy and feel like I want to do more things. I suspect the weight loss claim comes from an increase in energy? It hasn’t really made a difference in my sleep though.
I was concerned about the cost as well. If this is a concoction that I can mix myself, I’m sure it would be quite a bit less expensive. However, my HSA did cover the cost of Amberen as it’s manufactured by a bio-medical company. Otherwise, I wouldn’t have ordered it.
Back on topic, though … I’ve also noticed my pain level is waaaay down and I’m not confined to the sofa for now. I do feel encouraged with the Amberen.
We’re all wired differently, and what works for some may not work for you. If you can afford it, it’s worth a try. I’m going to finish my 3 month supply and if I can remember, I’ll visit again to let you know how it worked for me.
I *am* interested in what this RU-21 is an think I’ll do a little research on it ….
Thanks for the comments and for your research, Joe!
Merry Christmas!
Ramona, thanks for writing and I appreciate your candor. feel free to say what you like here. nobody sees your identity. Im happy that Amberen is helping some of your symptoms. The stuff in Amberen commercials about “#1 reason why women over 40 gain weight is because of a hormonal imbalance” is either a bunch of baloney in my opinion or I just dont know where they are getting that pice of evidence from. Either way, They have not shown any proof of weight loss but thats ok in my book as long as it helps with the symptoms of menopause, which several women have said, it has. That alone may make/Amberen something to look at. As for Ru21, some women are saying some interesting stuff about it also. If you can find it and its cheaper/does the same thing, it may be worth a try.
Thanks, Joe! I left another post at the bottom of the page today. But I did want to tell you that I do NOT believe that Amberen helps with weight loss OR hormone imbalaces. I’m not very pleased at the end of my first month and have decided to stop taking it. BIG ((((((sigh))))))
Ramona,
You may learn that supplementing Vit. D3 will make a beneficial difference. I learned that it lifted mood nicely. It has also helped overall health.
BUT, it has taken several years to get levels up to near 50, and those drop fast if I forget to take the D3 [I have been using 5000 to 10,000 iu's daily]. The Doc did the 25[OH]D blood test every several months to check it.
Some literature now indicates it is critical to get adequate vit. K2, especially when taking higher doses of D3, for both bone and heart health.
Joe
Back on the regular dose now for 2 weeks and although hot flashes/night sweats came back for several days they have not almost completely subsided. I will say the “uneasy/off” feeling has also subsided too on the lower dose.
I am, however, concerned what will happen when I go off in 4 more weeks. I’ve read some internet comments “beware of insomnia after going off amberen”, compared to withdrawal symptoms. We shall see. I will complete the 3 months (or in my case 2.5 months) regiment.
It is expensive though. And with the other RLS Rx’s I am on may not be able to continue. Will add back the Evening Primrose Oil and iCool if hot flashes, night sweats, etc.. return. The emotional roller coaster is horrific.
My 21 year old son commented this weekend, “Mom why are you always so agitated, anxious, sad, upset and negative.” I’m thinking, well let’s see, sleep deprivation menopause “emotional roller coaster” might have something to do with it…
PJ, I get that way also when I don’t sleep!
Science has proven repeatedly, that sleep deprivaton is literally “crazy-making”.
That also goes for having to work rotatin or changable shifts, which causes sleep deprivation related to being unable to force the body clock to rotate as fast as those shifts.
Upset sleep patterns = people off-balance.
It does not matter what the cause; sleep deprivation causes deranged behaviors that can be out-of-character for the person experiencing it, making overall syymptoms worse, and make them more succeptible to being manipulated psychologically/emotionally….keep that in mind when subjected to pleading teens and commercials/marketing!!!
I’ve been taking RU-21 since the end of October. I take 2 tablets per day, one in the morning and evening. I’ve stopped having night sweats and hot flashes. I love being able to sleep again!!
I’m curious about the Diatomaceous Earth someone mentioned in an earlier post. Does anyone have any personal experience with it?
Hi Michelle-
I looked back & see no post about this, but wondered if I might have been the one who wrote about it? I’ve been drinking diatomaceous earth for just over a month now. It didn’t do anything for the hot flashes, but it sure did help my hair! Not only did it stop falling out & start growing back in (visibly thicker)- but the actual hair is no longer coming in gray. It is now coming in at the previous blond/brown colour. In fact, I went over eight weeks before dying- where before I was lucky if I could even get to three weeks before the white showed up (especially at the front hairline).
It is nothing short of amazing! And I have a sack of it I bought off of ebay that will last the rest of my life (Permaguard brand is supposed to be the best, but I bought something else here in AU).
WOW! Never heard that of diatomacious earth. I would have thought it such fine, sharp little crystaline bits, it would cause irritation to the gut if used internally??
I have been using MSM dissolved in water, in a mist spry bottle, and applying once or twice a day, to “feed” the hair the sulphur. That has caused some people I know [and self] to get thicker hair growth returning–cannot speak to the color restoration though.
Has anybody used Amberen and had their joint pain stop?
Where can you buy Succinic Acid has anybody tried it instead of Amberen?
Janet, if you search the comments you’ll see people talking about a product called RU21 (hangover supplement) that has succinic acid. some have said it helped them.
Try googling “succinic acid supplements”–loads of listings of several kinds…I would be a bit careful about overseas offers. Looked like plenty to choose from though.
Hey, Joe and everyone else — I’ve gotta tell you guys that I’ve just completed my first month of the Ameren. I only took one day’s dose of the second month and have decided to stop it. I believe it’s made me GAIN weight. The last month, the weight has been piling on – and I’m really freaked out about it, so I quit. I need to lose 15 lbs.
I think I’m going to do some more research on vitamin therapy, etc. I actually prefer natural products over synthetic pharmaceuticals. So, although at 2 weeks I was excited about the Amberen, I’m feeling quite disappointed right now. Think I’ll do some more research on the RU21. I need some help!
Happy New Year!
Please share if you find anything.
Supplements promoted as really really awesome stuff, for whatever, but some people have odd reactions to.
Remember when Saw Palmetto was promoted for helping women grow larger breasts?
YEah—it can—right along with the rest of the body fattening up with the breasts!
Only ONE very old homeopathic reference book I found, described Saw Palmetto as being used for those with wasting diseases…”to pack flesh on”….which it does, nicely.
I took therapeutic doses of Lipoic Acid, Rx’d by the Doc, and blimped up like a beached whale.
NONE can figure why that happened–I can only guess it is sourced from something like a Saw Palmetto plant…though no one else seemed to ever have heard of that effect.
Along those lines, most supplements have fillers: many fillers are intended as flow agents or similar…yet, they have the effect of blocking absorption of the ingredients the user wants–both pharmaceuticals and supplements.
So, no way to really know what ingredients in Amberen might do to some, but not all, users.
Kind think we live in something of a guinea pig world.
Chi, the idea of being a guinea pig with some supplements is truer than a lot of people realize especially for things that pop up out of nowhere.
Wish I could “like” your comments!
Thanks guys …
Ramona, I will look into that. Its a good idea
I just wanted to update on my experience with RU-21. I dropped down to one tablet per day about a month ago and I’m still not having hot flashes or night sweats.
I agree with a previous post that someone made that we are all wired differently. I think that trial and error is needed within caution.
I took Amberen for about 9 weeks and then decided to take a break. I have now been off the Amberen for about 2 months. I had a few hot flashes after stopping but nothing like I used to have. I can now wear sweaters and sweatshirts without feeling like I’m going to die of heat exhaustion. I am planning on taking Amberen again for a few months if my hot flashes return which I’m sure they will since I am premenopausal.
Thank you, thank you for all of the wonderful information and opinions that everyone has given.
I am actually interested in trying diatomaceous earth. I was wondering if Tracy could comment on how long she has taken it and it she knows how long it should be taken for?
I’ve been on Aberen for 11 days. My sleep has gotten worse. I can not fall asleep and I wake up every hour and have a hard time falling back to sleep. I called the company and they told me to double the dose. They also said it shows it is working.
Has anybody else had this problem and will it work if I double the dose. Just thinking I should send it back before my 30 days are done.
Janet, this is so interesting. So you have a strange side effect and Amberen says to double the dose! Whats up with that? Do you know the qualifications of the person you spoke with on the phone? Was it a nurse? Did he/she ask you any questions about your health first before they blurted out to increase the dosage of Amberen? What number did you call?
So they said your insomnia is proof that Ambern is working. is that really what they said?
Anybody else have trouble sleeping or got that “double the dose” reply from Amberen?
Hi Joe
Thanks for the reply.
She was a nurse, she asked me if I was on any medication that would alter my hormone levels and if I had had my thyroid tested. I am not on any medication and I had my thyroid tested last year from a MD doctor who said I was normal.
I called the 1-800-222-3304 but they never answered, so I went on line and chatted with the person.
This is one thing she said “It is not uncommon for your symptoms to increase within the first few weeks of starting an Amberen course. This is a sign that Amberen is working, your body is responding to the product, causing a fluctuation of hormones. This should subside once your system gets acclimated to Amberen. We recommend taking 4 capsules per day up to 14 days; after that scale back to a single dose for the remainder of the course. It should not cause your symptoms to become worse. It should help to balance out your hormone levels. If you notice your symptoms are getting worse you can contact us and we can try reducing your regimen.”
So what do you think about what she is saying?
Janet, since Amberen -itself – has zero published peer reviewed clinical evidence – what the nurse is saying is not based on research. If anything, she may be basing what she says on how people are responding to Amberen – but this is not good enough proof for me. I’m actually kind of surprised that a nurse would say something like this.
And where is she getting this “we recommend 4 capsules up to 14 days” stuff from? What evidence shows this is the right about for people to use? Thanks for the phone number Janet. Ill let you know if I turn up anything
Hi Joe
My sleeping was not any better last night on and off all night. My hotflashes were a lot worse. When I was on the 4 pills.
I called back the nurse hotline and this is what she told me
In some cases, due to high lability (instability of body’s functions) this kind of resistance of the body to adjust has been recorded. In some instances, the withdrawal of ammonium succinate (the ingredient in the white capsules) has been shown to solve the issue partially if not completely. The results may vary, however we recommend eliminating the white capsule from your daily intake of Amberen for about one week, while continuing to consume the orange capsule daily. If you find this to be effective, please resume back to the single dose of Amberen (1 orange / 1 white capsule) as directed for the balance of the course.
Not sure what to do.
Hi Joe
I forgot to tell you that she said
The white capsule contain the ammonium succinate. The orange capsules contain all of the other ingredients.
What I can not figure out if she is telling me to take a break from the white one because that is causing my hotflashes and not sleeping will that problem not come back when I start the white tab up again.
Janet That’s so interesting because its the succinate that is the active ingredient in Amberen.
Anybody else having trouble sleeping with Amberen?
Janet & Joe;
The World health Organization has used saliva tests for hormone levels, and a tiny gizmo that reads mucus to help women tell when they are at the fertile point of their cycles [for birth control in 3rd world countries] for decades.
Cheap processes like these do not make much profit margin though.
I would consider this a fairly reliable test for hormones just about everywhere in the world, Except America, where doubt reigns supreme. [google: "World Health Organization, saliva test for hormones"]
Googling “BHRT reliability & safety”, there is an overload of data both for and against it—that against it appears to be American [so refer to above comment].
American science has been some of the best for so long; but the field’s general xenophobia about even considering research / data from elsewhere, has become increasingly ridiculous.
Decades ago, that caution was warranted, in large part.
Not so much, now.
As I remember the explanation given me years ago:
“Bioidentical hormones [BHRT] are identical enough to plug cleanly into receptor sites, reducing adverse effects in both number and severity.
Man made analogs of hormones, even those derived from mare’s urine which start out “natural”, have irregularities in how they plug into receptor sites, which causes more and worse adverse effects. Those irregularities are part of the pharmaceutical companies’ forming a patentable product.”
Using things like Wild yams to make hormones, is relatively easy, can be done in home kitchens, and cheap, not patentable [same as so many herbals used for healing].
Caveates regarding BHRT creams and other topicals [and herbals] might include:
==patients not controlling dose adequately over time can cause variability in results [hard to use exactly right amount of creme].
==the company that compounds the product, makes a difference in quality/reliability of product consistency, which can affect results.
==standardization between companies is not always certain, nor is standardization of any herbally derived medicine.
==prescribing only one or two hormones, and basing that only on symptoms assessment, is probably not adequate, and could produce adverse effects.
But using BHRT is pretty good, when it’s done right.
Over ten years, none of our patients complained [except: "the cream is so wonderful, I want to use it all over my skin, not just on the little spot for medicine!"]. [We used the hormone cremes from Women's International Health compounding pharmacy or one in Berkeley, CA, then].
Nutritional helps for menopausal and other issues,
can include therapeutic amounts of Omega3 fats [DHA ], which is between 1000 to 3000 mg. DHA Omega3 per day;
And Vitamin D3, based on your “25[OH]D” blood test, might be from 1000 to 10,000 ius per day.
YES, krill oil has good oils LIKE fish oil has, BUT it takes far more of it than the current company offering it advertizes. Krill pills do not equal fish oil pills, pill-for-pill.
(I have wondered, if we consumed enough krill oil to equal fish oil, would we turn pink like salmon do, from eating that?;-)
Removing stressors is key.
Getting aerobic exercise is key–even if all one can do is move slowly and breath deeply–getting that deep breathing is so important!
I took it for 3 mos. Felt better, slept better, no more night sweats, nicer to my people too! I lost 6 pounds. I ran out and have been out for 6 weeks. Hot flashes are back!
Kay, thanks for writing. Hopefully your hot flashes are gone now!
I am about to start this program of Amberen. Your experience was one of the only ones I read with good results. I did not look up the reviews before I ordered it and I would hope I will get results like yours! My main reason for getting it was for the belly fat. I have def put on more weight there in the last year and I have been post menapausel for quite a few years! No hot flashes or night sweats, but the weight gain has become a problem since it mostly is being stored as belly fat.
The guy I ordered from says the product has a 92% rate of success. I have never heard of it until I saw the infomercial on TV. Now I’m not sure if this product will do what it says. Too many people on this site were not happy with the results. I don’t want to put anything bad into my body and he claimed it was all natural with many studies over 35 years being done to prove it works!
When I get it I will check it out with my compounding pharmacist and see if they think anything in it will be bad for me. If it is I’m sending it back and if it isn’t ill try it and see if I get any good results in the removal of belly fat. Wish me luck.
Tango, for what its worth I really do hope it helps you. That said I see no good proof that Amberen reduces body fat. Still, I hope I’m wrong.
Hello Guys!
I ordered this product based on the ad promoting weight loss (abdominal area in particular). I’m 10lbs over my ideal weight, so I thought why not?
Even though I have not one of the other symptoms, I decided to give it a
try. Guess what? I barely took it for almost 2 weeks and would you believe
that besides gaining 2 xtra lbs, I ended up having to deal with hot flashes,
nausea, overall weakness, depression, etc.
I stopped taking it, and I’m starting to feel normal again. What in the world
make me suffer all those symptons? The Ammonium Succinate?
There’s no way I will attempt to take this product again, and felt so lousy
from the first day I started!!!
By the way I’m post menopausal. I’m one of the “lucky” ones who didn’t
have all those symptoms most women complaint about.
I don’t do pharmaceuticals of any kind, rather live a very “holistic” live
style. Thank you for this blog.
This product is horrendous!!! Why would anyone, especially menopausal women want to take this? This is rhetorical. Go NATURAL ladies. There are plenty of natural supplements available to us.
Thanks for taking the time do clarify so many things about this product!
You’re very welcome!
Joe – except for my VERY regular periods, I have some obvious symptoms of menopause (sleeplessness, low libido, hot flashes – especially in the face and neck and weight gain). I have not been diagnosed by my GYN as being in meno or premeno. My mother’s sisters all 3 were early menopausal (40, 41). I am 41. Just had my second and last child in 2010. I was going to try this supplement to minimize the symptoms (truth be told, mostly the weight gain). but now I’m concerned…if I am not in menopause, should I even bother?
Kristine B, good question and Im not sure of the answer. For what its worth, I don’t think it will hurt you to try it for a month to see if it helps. If it doesnt, then its been a small investment. if it does, then great.
Hello,
I have been trying to find a list of ingredients for Amberen and found this site with the most succinct information I have seen yet. I believe, after reading the article and comments, I could not take it. However I came across one comment that I would like to speak to. Someone, I can’t find the comment again, wrote of having restless legs…I have restless legs, one among many conditions…and I would like to share what I use to calm the legs and help with sleep.
I take calcium/magnesium citrate (more absorb-able in citrate form). I use Meijer’s Naturals brand and they include some vitamin k and vitamin d along with some other minerals. I take only half the recommended dose as it works very well in that amount and lasts twice as long. You can Google for the brand..although I imagine there are others that make similar products. The ingredients are listed. It takes care of the restless legs. I have had the condition for years and finally found this last year.
I take 1000 to 5000 IU liquid D3 (Sundown Naturals) with it in the evening before bedtime, although I have found the cal/mag combination will calm the legs…D helps the absorption and I am low in D. I have been so long in searching for something to quiet my restless legs that I felt compelled to share with anyone who has this sleep robbing affliction.
I would love to hear if anyone is finding any supplements for saggy skin…itchy skin…etc…The change in my skin nearly happened overnight! And I just started amberen. Stopped my 100g of progesterone first. I am 49…mild hot flashes…mild throwing off and on of the covers at night….mid-section slight weight gain. I’m trying to get a grip on this early!
Just saw a commercial for this product onTV and googled it out of curiosity. Your site came up as one of the top hits and i was impressed by the thorouhness of your review. In response to all of the ladies who are looking for help with the estrogen, a product that I have used for some pretty severe perimenopause symptoms with great success: http://www.amazon.com/Enzymatic-Therapy-Estrobalance-dim-Tablets/dp/B0013OUGOC/ref=cm_cr_pr_product_top
Hope that might help!
Thanks Julie, glad I was easy to find
I have been on Amberen for 8 days today. The first day, I slept through the night without waking up once. I thought these were going to be great. On day 7, I starting getting itchy, and had a rash on my neck, and on my side where my bra is touching my body. I thought it was something I ate, so today, I took my dose of Amberen.
Approximately 5 hours later, I have the worst rash of my life…it is all over my neck, my sides, under my breasts, on my back, on my legs and stomach, and it’s just starting to irritate my jaw line now. It’s awful!
I was so hopeful that these pills were going to be the answer for me. I’m usually up half the night kicking the covers off, and pulling them back on. I was hoping that if I stayed on these, that I would also show some sign of weight loss.
After this rash, and it’s far worse today than it was yesterday, I will have to go off of them. I’m very sad.
Has anyone else had an allergic reaction to these pills like I have?
I’ve taken estrace for years and allways wanted to get off of it. I did March 9-2013 and love Amberen, It works great..
For what its worth, I work as a phone rep for a company that represents Amberen. What I have been told regarding the MSG: Amberen uses a form referred to as MSLG. This is supposed to be a higher quality, pharmaceutical grade of MSG, different from what is in Chinese food, and in an extremely low amount. It is there to help with absorption of the product into the bloodstream. Would love to hear from anyone in the medical/pharma world about this?
Thank you so much for all your hard work. It has helped me so much-I started looking everything up about Amberen, and I knew most of them except for ammonium succinate and then I saw your web page. Thank you for taking the time to do all this research!
Sherry, glad I was able to help you with your research
I’ve been on Amberen for a week. My sleeping is WAY better, but it gives me a HORRENDOUS stomach ache when I take it, even after eating.
I’ve been on Amberen for about two weeks…after 7 days, I called them because I was feeling “jumpy” and irritable. The male nurse said to Take 1 dose every other day and see if that helps. Coincidentally, I started having sore gums. Yesterday was an “off” day and my gums felt better…took it today and my gums are really killing me.
Off Amberen starting tomorrow (and will get my $$ back) and then off to the Dentist!!
It did help me sleep through the night, but I’m not sleeping well with my gums on fire. Amberen is the only change in my diet and I’ve never had gum problems before.
Amberen does not work. I’m returning it immediately – gained 3 pounds since I started taking it a week ago.
Thank you for this review of Amberen ingredients and the discussion posts. A cpap machine recently improved my sleep and took my chest pain away. Sleep apnea (the bad snoring is sign) worsened around same decade as menopause. Occasional 500mg Magnesium supplement and 5mg of Melatonin helps.
Good rest is helping my irritability and fatigue. Less fatigue provides energy to exercise. Exercise helps me feel better but weight gain remains problematic.
Wondering if succinic acid could help with night sweats. My husband had heard all the Amberen ads while listening to radio. I appreciated recognizing I am not alone in all the symptoms of many menopausal women but the ad hype for Amberen seemed too good to be true.
Appears to be one of the many ad campaigns promoting The Pill of Health which is always tempting but for me, these pill promises have been mostly expensive false hopes.
Appreciate your work in searching out what the ingredients and research was behind the product.
Karen, glad you found my review helpful. Hard to say if succinic acid would help with night sweats. The good news is its a lot less expensive than Amberen. Here is one brand of succinic acid I found on amazon. there are others there also. Id guess that you would have your answer in about an month or so. If it helps, do let me know.
Janet, when the nurse says that reports “have been recorded” Id ask where. It just sounding like fancy talk to me. I could be wrong but it sounds to me like they just want to keep you taking the stuff.
I say get off of Amberen and see if your sleep improves. At least decrease the amount and see if that helps. Keep me posted.
I’ve decided to get off the product before it is too late to get my money back.
Do you have any other suggestions for waking up 6 times during the night, hot flashes and joint pain.
I have tried a lot of products and nothing seems to work.
Do you know anything about Bio-Identicals, but that seems to be so expensive and they will not promise that will work either.
Hi Janet, as I see it “bio-identical” hormones are really “bio-similar”. The name bioidentical is a marketing word. Hormones taken from plants are not identical to human hormones. As such Im not sure how well they would work in people. They might or might not. I just don’t know. I’d talk to a pharmacist or endocrinologist about this as they are very smart about chemistry and this stuff.
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